concept

TDP-43 PATHOLOGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 PATHOLOGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

4Hypotheses

2Analyses

16Outgoing

12Incoming

0Experiments

4Debates

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💡 Concept Info

Name	TDP-43 PATHOLOGY

Pathway Diagram

graph TD
    TDP_43_PATHOLOGY["TDP-43 PATHOLOGY"]
    TDP_43_PATHOLOGY -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TDP_43_PATHOLOGY -.biomarker for.-> Frontotemporal_Lobar_Degenerat["Frontotemporal Lobar Degeneration"]
    TDP_43_PATHOLOGY -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    TDP_43_PATHOLOGY -->|"correlates_with"| Cognitive_Decline["Cognitive Decline"]
    TDP_43_PATHOLOGY -->|"expressed in"| Hippocampus["Hippocampus"]
    Plasma_Ev_Tdp_43_Levels["Plasma Ev Tdp-43 Levels"] -.biomarker for.-> TDP_43_PATHOLOGY
    ATXN2["ATXN2"] -->|"contributes to"| TDP_43_PATHOLOGY
    APOE["APOE"] -->|"risk_factor_for"| TDP_43_PATHOLOGY
    APOE4["APOE4"] -->|"risk_factor_for"| TDP_43_PATHOLOGY
    STMN2["STMN2"] -.biomarker for.-> TDP_43_PATHOLOGY
    UNC13A["UNC13A"] -.biomarker for.-> TDP_43_PATHOLOGY
    RIPK1["RIPK1"] -->|"promotes"| TDP_43_PATHOLOGY

Outgoing (16)

Target	Relation	Type	Str
Frontotemporal Lobar Degeneration	biomarker_for	disease	0.95
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.95
Alzheimer's Disease	associated_with	disease	0.92
Alzheimer's Disease	biomarker_for	disease	0.90
Cognitive Impairment	associated_with	phenotype	0.90
cGAS-STING pathway	associated_with	pathway	0.90
cognitive decline in Alzheimer's patients	causes	disease	0.85
Cognitive Decline	correlates_with	phenotype	0.85
Neurofibrillary Tangles	associated_with	biomarker	0.85
Hippocampal Sclerosis	associated_with	disease	0.85
Cognitive Impairment	associated_with	phenotype	0.85
Alzheimer's Disease severity	drives	phenotype	0.83
Hippocampus	expressed_in	brain_region	0.82
Cognitive Impairment	causes	symptom	0.80
Hippocampal Sclerosis	associated_with	disease	0.78
axonal injury	causes	mechanism	0.70

Incoming (12)

Source	Relation	Type	Str
Plasma Ev Tdp-43 Levels	biomarker_for	biomarker	0.94
ATXN2	associated_with	gene	0.90
Nuclear Pore Complex Dysfunction	causes	mechanism	0.90
APOE	risk_factor_for	gene	0.90
Ataxin-2 Reduction	associated_with	mechanism	0.90
UNC13A	biomarker_for	gene	0.88
APOE4	risk_factor_for	gene	0.88
STMN2	biomarker_for	gene	0.88
RIPK1	promotes	protein	0.85
APOE4	associated_with	gene	0.80
CGAS	associated_with	gene	0.80
TMEM106B	regulates	gene	0.70

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Glial Neuroinflammatory Amplification by TDP-43 Pathology	0.680	neurodegeneration	What mechanisms underlie TDP-43's contri
TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signat	0.483	-	Epigenetic clocks as biomarkers for Alzh
Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology	0.460	neuroinflammation	How does chronic cGAS/STING activation d
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase