Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PS65-UB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PS65-UB |
graph TD
PS65_UB[PS65-UB]
PS65_UB -->|involved_in| Mitophagy[Mitophagy]
PS65_UB -.biomarker for.-> Mitochondrial_Damage[Mitochondrial Damage]
PS65_UB -.biomarker for.-> Lewy_Body_Dementia[Lewy Body Dementia]
PS65_UB -.biomarker for.-> Alzheimer_s_Disease[Alzheimer's Disease]
PS65_UB -.biomarker for.-> Parkinson_s_Disease[Parkinson's Disease]
PINK1[PINK1] -->|produces| PS65_UB
PINK1_PRKN_pathway[PINK1-PRKN pathway] -->|produces| PS65_UB
APOE4[APOE4] -->|modulates| PS65_UB
ZMIZ1[ZMIZ1] -->|modulates| PS65_UB
mtDNA_variation[mtDNA variation] -->|correlates_with| PS65_UB| Target | Relation | Type | Str |
|---|---|---|---|
| Mitophagy | involved_in | process | 0.95 |
| Mitochondrial Damage | biomarker_for | phenotype | 0.92 |
| Lewy Body Dementia | biomarker_for | disease | 0.90 |
| Mitophagy | biomarker_for | process | 0.90 |
| Alzheimer's Disease | biomarker_for | disease | 0.90 |
| Parkinson's Disease | biomarker_for | disease | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | produces | entity | 0.95 |
| Neurofibrillary Tangles | associated_with | phenotype | 0.88 |
| Lewy Body Pathology | associated_with | phenotype | 0.88 |
| APOE4 | modulates | gene | 0.85 |
| PINK1-PRKN pathway | produces | pathway | 0.85 |
| APOE Ε4 | associated_with | gene | 0.85 |
| ZMIZ1 | modulates | gene | 0.80 |
| mtDNA variation | correlates_with | mechanism | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PS65-UB in their description or question text
No additional research found