SciDEX — AMYLOID-Β

Outgoing (72)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
ALZHEIMER'S DISEASE	contributes_to	entity	0.95
Alzheimer'S Disease	biomarker_for	disease	0.95
Inflammation	associated_with	process	0.95
alzheimer_disease	biomarker_for	disease	0.95
Alzheimer Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Neurofibrillary Tangles	causes	biomarker	0.95
Alzheimer Disease	biomarker_for	disease	0.95
Alzheimer's Disease	involved_in	disease	0.95
ALZHEIMER	causes	disease	0.95
PANoptosis	activates	process	0.92
Alzheimer's Disease	causes	disease	0.90
Microglia	activates	cell_type	0.90
Alzheimer's Disease	involved_in	disease	0.90
Alzheimer's disease	biomarker_for	disease	0.90
Astrocytes	modulates	cell_type	0.90
Amyloid Plaques	associated_with	entity	0.90
Alzheimer's disease	associated_with	disease	0.90
ALZHEIMER'S DISEASE	biomarker_for	disease	0.90
Post-Stroke Cognitive Impairment	involved_in	disease	0.89
Tau Phosphorylation	associated_with	process	0.85
tau	promotes	protein	0.85
cognitive decline	drives	phenotype	0.85
Microglia	activates	cell_type	0.85
Alzheimer'S Disease	causes	disease	0.85
synaptopathy	causes	process	0.85
Proteostasis dysfunction	contributes_to	process	0.85
Intracellular Aggregation	involved_in	process	0.85
plasma biomarkers	biomarker_for	process	0.85
pathological seeds	associated_with	protein	0.85
Mitochondrial Stress	causes	process	0.85
MICROGLIA	activates	cell_type	0.80
neurodegenerative diseases	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Alzheimer's disease	causes	disease	0.80
synaptic dysfunction	causes	process	0.80
synapse loss	causes	process	0.80
Alzheimer's Disease	causes	disease	0.80
amyloid-related imaging abnormalities	causes	phenotype	0.80
microglial_activation	activates	mechanism	0.80
Alzheimer's disease	causes	disease	0.70
protein aggregates	causes	process	0.70
Alzheimer's disease	causes	disease	0.70
apoptosis	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
mitophagy	inhibits	process	0.70
Tau	mediates	protein	0.70
Tau	associated_with	protein	0.70
lipid droplet formation	activates	process	0.70

Incoming (291)

Source	Relation	Type	Str
Donanemab	targets	drug	0.95
donanemab	binds_to	drug	0.95
Lecanemab	targets	drug	0.95
BACE1	associated_with	entity	0.95
LRP1-targeted Polymersomes	targets	drug	0.95
Donanemab	targets	drug	0.95
Lecanemab	targets	drug	0.95
Modified Antibody	targets	drug	0.95
LRP1	regulates	entity	0.95
Modified Antibody	targets	drug	0.95
APP	produces	gene	0.95
Γ-SECRETASE	produces	enzyme	0.95
APP	associated_with	protein	0.95
APP	associated_with	gene	0.95
Lecanemab	targets	drug	0.92
Donanemab	targets	drug	0.92
APOE	associated_with	gene	0.90
Ceramide	contributes_to	compound	0.90
APOE ε2	inhibits	gene	0.90
TAU	interacts_with	protein	0.90
APOE	interacts_with	gene	0.90
Amyloid Precursor Protein	associated_with	protein	0.90
Presenilin Complex	associated_with	entity	0.90
MTOR	promotes	gene	0.90
apoE	interacts_with	protein	0.90
PSEN1	associated_with	protein	0.90
aducanumab	targets	drug	0.90
PSEN1	upregulates	gene	0.90
CLU	interacts_with	protein	0.90
PSEN1	upregulates	gene	0.85
PSEN2	upregulates	gene	0.85
Mtor Inhibition	associated_with	mechanism	0.85
TFEB	promotes	protein	0.85
Hdac3 Inhibition	associated_with	mechanism	0.85
Aducanumab	targets	drug	0.85
Lysosomal Degradation	degrades	process	0.85
GLP-1R	prevents	protein	0.85
APOE	associated_with	protein	0.85
amyloid hypothesis	associated_with	pathway	0.85
CYP46A1	regulates	gene	0.80
Alzheimer's Disease	causes	disease	0.80
ABCA7	transports	gene	0.80
CROCETIN	promotes clearance of	compound	0.80
HMGCR	regulates	gene	0.80
VDAC1	interacts_with	gene	0.80
NBR1	regulates	protein	0.70
BECN1	regulates	protein	0.70
depression	associated_with	disease	0.70
autophagy	protects_against	process	0.70
autophagy	regulates	process	0.70

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Title & PMID	Authors	Journal	Year	Citations
No papers found

Hypotheses and analyses mentioning AMYLOID-Β in their description or question text

Name	AMYLOID-Β
Key Genes/Proteins	APP, CLU, PSEN1
Related Diseases	Alzheimer Disease, Alzheimer's disease, Alzheimer's Disease, neurodegenerative diseases

AMYLOID-Β

Understanding Entity Pages

Pathway Diagram

Outgoing (72)

Incoming (291)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research