gene

DGAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DGAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

171Connections

2Hypotheses

4Analyses

50Outgoing

39Incoming

0Experiments

4Debates

Summary

DGAT1 is a gene implicated in neurodegeneration research. Key relationships include: activates, co discussed, inhibits. Associated with Cancer, Glioblastoma, Ms. Connected to 56 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DGAT1
Full Name	Diacylglycerol O-Acyltransferase 1
Chromosome	8q24.3
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of triglyceride synthesis enzyme
Mechanism of Action	Small molecule inhibitor of triglyceride synthesis enzyme
Primary Expression	multiple cell types within the CNS:
Druggability	Low (0.41)
Clinical Stage	Phase III
Molecular Weight	53 kDa
Amino Acids	460 aa
Exons	17
Pathways	Astrocyte reactivity signaling
UniProt ID	Q3KQR6
Ensembl ID	ENSG00000185088
OMIM	604035
GeneCards	DGAT1
Human Protein Atlas	DGAT1
Associated Diseases	glioblastoma, neurodegeneration, stroke
Known Drugs/Compounds	Pradigastat
Interactions	AMPK, AND, APOA1, APP, ATGL, C3
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Astrocyte-Specific DGAT1 Inhibition to Prevent Lip Lipid Droplet Dynamics as Therapeutic Lever
KG Connections	171 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DGAT1 — AlphaFold Q3KQR6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DGAT1 — Diacylglycerol O-Acyltransferase 1

gene · 1605 words

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DGAT1 Protein

protein · 603 words

→

Pathway Diagram

graph TD
    DGAT1["DGAT1"]
    DGAT1 -->|"interacts"| Zika_Virus_Capsid_Protein["Zika Virus Capsid Protein"]
    DGAT1 -->|"activates"| Cancer["Cancer"]
    DGAT1 -->|"activates"| Glioblastoma["Glioblastoma"]
    DGAT1 -->|"activates"| Tumor["Tumor"]
    DGAT1 -->|"activates"| Ms["Ms"]
    DGAT1 -->|"inhibits"| Cholesterol["Cholesterol"]
    DGAT1 -->|"inhibits"| Lipid_Metabolism["Lipid Metabolism"]
    h_7d4a24d3["h-7d4a24d3"] -->|"targets"| DGAT1
    SOAT1["SOAT1"] -->|"inhibits"| DGAT1
    GBM["GBM"] -->|"activates"| DGAT1
    CD36["CD36"] -->|"activates"| DGAT1
    APOA1["APOA1"] -->|"activates"| DGAT1
    AND["AND"] -->|"activates"| DGAT1
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"activates"| DGAT1
    PLIN2["PLIN2"] -->|"activates"| DGAT1
    GENES["GENES"] -->|"activates"| DGAT1

Outgoing (132)

Target	Relation	Type	Str
TRIACYLGLYCEROL SYNTHESIS	regulates	entity	0.95
LIPID DROPLET STORAGE	regulates	entity	0.95
lipid droplet	involved_in	process	0.95
triacylglycerol synthesis	associated_with	process	0.90
lipid droplet storage	upregulates	process	0.90
triacylglycerol biosynthesis	regulates	process	0.90
GLIOBLASTOMA	associated_with	entity	0.90
Lipid Droplet Formation	involved_in	process	0.90
ZIKV CAPSID PROTEIN	interacts_with	protein	0.88
Lipid Metabolism	associated_with	process	0.85
LIPID METABOLISM	involved_in	entity	0.85
Zikv Capsid Protein	interacts_with	protein	0.85
Neurodegeneration	involved_in	process	0.85
endolysosomal lipid accumulation	suppresses	phenotype	0.85
neurodegeneration	protects_against	phenotype	0.80
ZIKA VIRUS INFECTION	contributes_to	entity	0.80
tauopathy	therapeutic_target	disease	0.75
therapeutic_target	therapeutic_target	process	0.70
lipid droplet formation	catalyzes	process	0.70
DGAT2	activates	gene	0.70
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
SOAT1	associated_with	gene	0.60
RNA	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
Ras	activates	protein	0.60
Cholesterol	associated_with	pathway	0.60
CANCER	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Erk	inhibits	protein	0.60
Ras	inhibits	protein	0.60
glioblastoma	protects_against	disease	0.60
GBM	protects_against	gene	0.60
SOAT1	protects_against	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
NR1H3	regulates	entity	0.60
PLIN2	regulates	entity	0.60
SOAT1	regulates	entity	0.60
SOAT1	activates	gene	0.60
GBM	activates	gene	0.60
SOAT1	inhibits	gene	0.60
neurodegeneration	associated_with	disease	0.60
GBM	expressed_in	entity	0.60
mitochondrial function	participates_in	pathway	0.60
SOAT1	expressed_in	entity	0.60

Incoming (39)

Source	Relation	Type	Str
h-7d4a24d3	targets	hypothesis	0.80
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
APOA1	regulates	entity	0.60
CD36	regulates	entity	0.60
DGAT1 AND SOAT1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
APOA1	activates	gene	0.60
ATP7B	causes	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
GENES	activates	gene	0.60
SOAT1	inhibits	gene	0.60
SOAT1	activates	gene	0.60
GBM	activates	gene	0.60
CD36	activates	gene	0.60
ACAT1	associated_with	gene	0.55
ATGL	interacts_with	gene	0.55
AMPK	activates	gene	0.55
APP	activates	gene	0.55
C3	inhibits	gene	0.55
SOAT1	interacts_with	gene	0.53
APOA1	co_expressed_with	gene	0.50
CD36	co_expressed_with	gene	0.50
CLOCK	debate_co_mention	gene	0.45
BMAL1	debate_co_mention	gene	0.45
DGAT1 Protein	references	protein	0.40
KCNK2	co_discussed	gene	0.40
TET2	co_discussed	gene	0.40
PIEZO1	co_discussed	gene	0.40
P2RX7	co_discussed	gene	0.40
CLOCK	co_discussed	gene	0.40
PLIN2	co_discussed	gene	0.40
SOAT1	co_discussed	gene	0.40
P2RY1	co_discussed	gene	0.40
MIRO1	co_discussed	gene	0.40
C3	co_discussed	gene	0.40
G3BP1	co_discussed	gene	0.40
HK2	co_discussed	gene	0.40
BMAL1	co_discussed	gene	0.40

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet	0.510	lipidomics	Lipid metabolism dysregulation in Alzhei
Lipid Droplet Dynamics as Therapeutic Lever	0.455	neurodegeneration	Which specific metabolic pathways in APO

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning DGAT1 in their description or question text

No additional research found

DGAT1

Understanding Entity Pages

Summary

Wiki Pages (2)

DGAT1 — Diacylglycerol O-Acyltransferase 1

DGAT1 Protein

Pathway Diagram

Outgoing (132)

Incoming (39)

Targeting Hypotheses (2)

Mentioning Analyses (4)

Lipid metabolism dysregulation in Alzheimer's disease: membrane rafts, gangliosi

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (4)

How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pa

Astrocyte reactivity subtypes in neurodegeneration

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Related Research