concept

YTHDF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YTHDF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	YTHDF1
Key Genes/Proteins	AGING, Akt, AKT, Albumin, ALKBH5, ANG
Related Diseases	Aging, Als, ALS
Related Pathways	Autophagy, autophagy pathway

Pathway Diagram

graph TD
    YTHDF1["YTHDF1"]
    style YTHDF1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    YTHDF1 -->|"binds"| m6A_Modification["m6A Modification"]
    YTHDF1 -->|"binds"| PIEZO2([PIEZO2])
    YTHDF1 -->|"regulates"| Translation_Fidelity["Translation Fidelity"]
    YTHDF1 -->|"involved_in"| M6a_Epitranscriptomic_Modifica["M6a Epitranscriptomic Modification"]
    YTHDF1 -->|"mediates"| m6A_Epitranscriptomic_Modifica["m6A Epitranscriptomic Modification"]
    YTHDF1 -->|"contributes to"| Cancer["Cancer"]
    YTHDF1 -->|"interacts"| ALS["ALS"]
    YTHDF1 -->|"target for"| Als["Als"]
    YTHDF1 -->|"target for"| Aging["Aging"]
    GENES([GENES]) -->|"contributes to"| YTHDF1
    HNRNPA2B1([HNRNPA2B1]) -->|"interacts"| YTHDF1
    WTAP([WTAP]) -->|"contributes to"| YTHDF1
    RNA([RNA]) -->|"contributes to"| YTHDF1
    ALKBH5([ALKBH5]) -->|"contributes to"| YTHDF1
    AND([AND]) -->|"interacts"| YTHDF1
    FTO([FTO]) -->|"contributes to"| YTHDF1
    CLPP([CLPP]) -->|"target for"| YTHDF1
    LONP1([LONP1]) -->|"target for"| YTHDF1
    SNAP29([SNAP29]) -->|"target for"| YTHDF1

Outgoing (94)

Target	Relation	Type	Str
m6A Modification	associated_with	process	0.95
N6-Methyladenosine	binds	compound	0.95
PIEZO2	regulates	gene	0.95
PIEZO2	binds	gene	0.95
Translation Fidelity	regulates	process	0.85
mRNA translation	regulates	process	0.80
ATG14	associated_with	protein	0.80
ATG2A	associated_with	protein	0.80
m6A Epitranscriptomic Modification	mediates	process	0.75
Proteostasis	modulates	process	0.75
M6a Epitranscriptomic Modification	involved_in	process	0.75
Fibrosis	regulates	disease	0.65
Als	encodes	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	contributes_to	disease	0.65
Aging	encodes	disease	0.65
Neurodegeneration	encodes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Mtor	associated_with	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
LONP1	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
Pi3K	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60
Akt	therapeutic_target	protein	0.60
Igf	therapeutic_target	protein	0.60

Incoming (61)

Source	Relation	Type	Str
RNA	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
PIEZO	regulates	gene	0.60
PIEZO1	activates	gene	0.60
POSTN	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ANG	activates	gene	0.60
RNA	regulates	gene	0.60
IGF2BP1	interacts_with	gene	0.60
CANCER	contributes_to	gene	0.60
ELAVL2	encodes	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60
TDP-43	encodes	gene	0.60
STX17	encodes	gene	0.60
RAB5	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	encodes	gene	0.60
ALS	encodes	gene	0.60
IGF2BP1	encodes	gene	0.60
MAPK	encodes	gene	0.60
RAB11	encodes	gene	0.60
ELAVL2	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
METTL3	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
GENES	contributes_to	gene	0.60
HNRNPA2B1	interacts_with	gene	0.60
WTAP	contributes_to	gene	0.60
ALKBH5	contributes_to	gene	0.60
FTO	contributes_to	gene	0.60
METTL3	regulates	gene	0.60
CLPP	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
PIEZO2	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
STX17	associated_with	gene	0.60
WNT	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
FUS	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AGING	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YTHDF1 in their description or question text

No additional research found