concept

CD86

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD86: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

26Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CD86
Key Genes/Proteins	AIF1, APP, C1QA, C1QB, C3AR1, CCR1
Related Pathways	complement cascade

Pathway Diagram

graph TD
    CD86[CD86]
    CD86 -.biomarker for.-> M1_pro_inflammatory_phenotype[M1 pro-inflammatory phenotype]
    CD86 -->|expressed in| microglia[microglia]
    CD86 -->|stabilizes| NEURON[NEURON]
    CD86 -.biomarker for.-> neuroinflammation[neuroinflammation]
    CD86 -->|activates| TLR4[TLR4]
    CD86 -->|participates in| complement_cascade[complement cascade]
    CD86 -->|regulates| CR1[CR1]
    CD86 -->|inhibits| TNF[TNF]
    CD86 -->|activates| NLRP3[NLRP3]
    TRETINOIN__ATRA_[TRETINOIN (ATRA)] -->|targets| CD86
    CD38[CD38] -->|activates| CD86
    CD206[CD206] -->|activates| CD86
    CD163[CD163] -->|activates| CD86
    CD80[CD80] -->|activates| CD86
    APP[APP] -.biomarker for.-> CD86

Outgoing (26)

Target	Relation	Type	Str
M1 pro-inflammatory phenotype	biomarker_for	cell_type	0.70
microglia	expressed_in	cell_type	0.70
NEURON	stabilizes	cell_type	0.70
neuroinflammation	activates	disease	0.60
ROS	activates	gene	0.60
stem cells	expressed_in	cell_type	0.60
PKC	activates	gene	0.60
NLRP3	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
METTL3	activates	gene	0.60
YTHDF1	activates	gene	0.60
mitochondrial function	participates_in	pathway	0.60
neuroinflammation	biomarker_for	disease	0.60
TLR4	activates	gene	0.60
CSF1R	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
complement cascade	participates_in	pathway	0.60
CR1	regulates	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	activates	gene	0.60
TNF	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
NEUROINFLAMMATION	expressed_in	phenotype	0.55
IL-10	expressed_in	gene	0.55
neurons	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
TRETINOIN (ATRA)	targets	drug	0.80
CD206	activates	gene	0.60
CD163	activates	gene	0.60
CD80	activates	gene	0.60
CD38	activates	gene	0.60
AIF1	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR1	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CD4	associated_with	gene	0.60
APP	biomarker_for	gene	0.60
APP	protects_against	gene	0.60
CD206	expressed_in	gene	0.60
SPINAL CORD	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD86 in their description or question text

No additional research found