protein 918 words KG: TYROBPPROTEIN
Contents

TYROBP/DAP12 Protein

🔬 Protein Info
Gene SymbolTYROBP
AliasesDAP12
Chromosome19q13.12
Protein TypeAdaptor Protein
Functionis a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary ExpressionMicroglia, Monocytes, NK cells, Osteoclasts
Molecular Weight12.1 kDa
Amino Acids113 aa
PathwaysInnate Immunity
UniProt IDQ9Y241
NCBI Gene ID7305
Ensembl IDENSG00000111653
OMIM605712
GeneCardsTYROBP
Human Protein AtlasTYROBP
Associated DiseasesAging, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
Known Drugs/CompoundsBERBERINE
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
SciDEX HypothesesTYROBP (DAP12) Conditional Antagonism for Early-St
KG Connections383 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (9)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (8)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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