protein 1,246 words KG: TYROBP
Contents

TYROBP Protein (DAP12)

🔬 Protein Info
Gene SymbolTYROBP
AliasesDAP12
Chromosome19q13.12
Protein TypeAdaptor Protein
Functionis a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary ExpressionMicroglia, Monocytes, NK cells, Osteoclasts
Molecular Weight12.1 kDa
Amino Acids113 aa
PathwaysInnate Immunity
UniProt IDQ9Y241
NCBI Gene ID7305
Ensembl IDENSG00000111653
OMIM605712
GeneCardsTYROBP
Human Protein AtlasTYROBP
Associated DiseasesAging, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
Known Drugs/CompoundsBERBERINE
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
SciDEX HypothesesTYROBP (DAP12) Conditional Antagonism for Early-St
KG Connections383 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (15)

TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (11)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (4)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

TYROBP interacts_with TREM2
TYROBP interacts_with SIRP1β
TYROBP interacts_with CD33
TYROBP interacts_with CR3
TYROBP associated_with alzheimer_disease
TYROBP activates RANK
TYROBP associated_with APP
TYROBP associated_with TREM2
TYROBP associated_with PSEN1
TYROBP associated_with CD33

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