protein 1,263 words KG: TRIM28
Contents

TRIM28 (KAP1) Protein

🔬 Protein Info
Gene SymbolTRIM28
Full NameTranscriptional Intermediary Factor 1 Beta (TIF1β)
AliasesTranscriptional Intermediary Factor 1 Beta
Protein FamilyTRIM family, transcriptional co-repressors
FunctionUpon KRAB-ZFP binding to DNA, TRIM28 is recruited through interaction with the KRAB domain.
Subcellular LocalizationNucleus (predominantly), also in cytoplasm
Molecular Weight110 kDa (835 amino acids)
Amino Acids835 aa
PathwaysFerroptosis
UniProt IDQ13263
GeneCardsTRIM28
Human Protein AtlasTRIM28
Associated Diseasesneurodegeneration
InteractionsAND, CANCER, DNA, FERROPTOSIS, HDAC5, RAD18
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (10)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
HDAC5 Gene
gene · KG edge: activates
RAD18 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TRIM28 inhibits HDAC5
TRIM28 activates SLC7A11
TRIM28 activates STAT6
TRIM28 activates HDAC5
SLC7A11 activates TRIM28
STAT6 activates TRIM28
HDAC5 activates TRIM28
HDAC5 phosphorylates TRIM28
SLC7A1 co_discussed TRIM28
STING co_discussed TRIM28

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