gene

SLC7A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC7A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

3Hypotheses

0Analyses

11Outgoing

12Incoming

1Experiments

0Debates

Summary

Solute Carrier Family 7 Member 1: High-affinity cationic amino acid transporter mediating arginine uptake in neurons and vascular endothelium

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🧬 Gene Info

Gene Symbol	SLC7A1
Chromosome	19p13.2
Protein Type	Transporter
Function	is a high-affinity transmembrane transporter that mediates cellular uptake of cationic amino acids, particularly L-arginine, L-lysine, and L-ornithine[@mann2003].
Amino Acids	629 aa
Exons	14
Pathways	Ferroptosis
UniProt ID	P30825
NCBI Gene ID	6541
Ensembl ID	ENSG00000147614
GeneCards	SLC7A1
Human Protein Atlas	SLC7A1
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC7A1 — AlphaFold P30825 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC7A1["SLC7A1"]
    Ferroptosis["Ferroptosis"]
    SLC7A1 -.->|"inhibits"| Ferroptosis
    SLC7A11(["SLC7A11"])
    SLC7A1 -->|"co_discussed"| SLC7A11
    STING(["STING"])
    SLC7A1 -->|"co_discussed"| STING
    WAS(["WAS"])
    SLC7A1 -->|"co_discussed"| WAS
    STAT6(["STAT6"])
    SLC7A1 -->|"co_discussed"| STAT6
    ACSL4(["ACSL4"])
    ACSL4 -->|"co_discussed"| SLC7A1
    GENES(["GENES"])
    GENES -->|"co_discussed"| SLC7A1
    GPX4(["GPX4"])
    GPX4 -->|"co_discussed"| SLC7A1
    HO_1(["HO-1"])
    HO_1 -->|"co_discussed"| SLC7A1
    style SLC7A1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (11)

Target	Relation	Type	Str
Boronophenylalanine	mediates	compound	0.95
HeLa	expressed_in	cell_type	0.90
Ferroptosis	inhibits	process	0.90
Cervical Cancer	biomarker_for	disease	0.85
Ferroptosis	regulates	process	0.85
SLC7A11	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
STAT6	co_discussed	gene	0.50
TRIM2	co_discussed	gene	0.50
TRIM28	co_discussed	protein	0.50
WAS	co_discussed	protein	0.50

Incoming (12)

Source	Relation	Type	Str
NCOA4	co_discussed	protein	0.50
HDAC5	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
HO-1	co_discussed	protein	0.50
OGT	co_discussed	gene	0.50
AUTOPHAGY	co_discussed	gene	0.50
RNA	co_discussed	gene	0.50
LYSOSOME	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
ACSL4	co_discussed	gene	0.50
GPX4	co_discussed	gene	0.50
NRF2	co_discussed	gene	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce	0.620	-	Ferroptosis in ALS and motor neuron dise
EP4 Receptor Agonism for SLC7A11 Upregulation	0.550	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC7A1 in their description or question text

No additional research found