gene 2,027 words KG: TRIM25
Contents

TRIM25 Gene (Tripartite Motif Containing 25)

🧬 Gene Info
Gene SymbolTRIM25
Full NameTRIM25 (Tripartite Motif Containing 25)
Chromosome17q11.2
Protein TypeGene
Functionencodes an E3 ubiquitin ligase that plays critical roles in multiple cellular processes including innate immunity, mitochondrial dynamics, and protein quality control.
Subcellular Localizationand activity
Molecular Weight55 kDa
Amino Acids504 aa
Exons6
PathwaysMitophagy
UniProt IDQ9C0B1
NCBI Gene ID11067
Ensembl IDENSG00000120937
OMIM606112
GeneCardsTRIM25
Human Protein AtlasTRIM25
Associated Diseasescerebral ischemia-reperfusion injury
InteractionsAND, APOE, ATAD3A, AUTOPHAGY, BNIP3, BRCA2
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (19)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Mitochondria
entity · KG edge: regulates
BNIP3 Gene
gene · KG edge: activates
BRCA2 Gene
gene · KG edge: activates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: degrades
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

TRIM25 activates PINK1/Parkin signaling pathway
TRIM25 causes cerebral ischemia-reperfusion injury
PARKIN activates TRIM25
P62 associated_with TRIM25
TRIM25 activates PINK1
LC3 activates TRIM25
P62 activates TRIM25
TRIM25 activates BRCA2
MECOM activates TRIM25
TRIM25 activates EGFR

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