concept

TGF-BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF-BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

2Hypotheses

1Analyses

29Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	TGF-BETA
Key Genes/Proteins	AKT, APOE, APP, BACE1
Related Diseases	Als, ALZHEIMER'S DISEASE, Atherosclerosis, ATHEROSCLEROSIS, CANCER

Pathway Diagram

graph TD
    TGF_BETA["TGF-BETA"]
    TGF_BETA -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    TGF_BETA -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    TGF_BETA -->|"activates"| METASTASIS["METASTASIS"]
    TGF_BETA -->|"activates"| FIBROSIS["FIBROSIS"]
    TGF_BETA -->|"implicated in"| CANCER["CANCER"]
    TGF_BETA -->|"activates"| AGING["AGING"]
    TGF_BETA -->|"activates"| EGFR["EGFR"]
    TGF_BETA -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    CYTOKINES["CYTOKINES"] -->|"regulates"| TGF_BETA
    CANCER -->|"regulates"| TGF_BETA
    TNF["TNF"] -->|"activates"| TGF_BETA
    IL_6["IL-6"] -->|"regulates"| TGF_BETA
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TGF_BETA
    VEGF["VEGF"] -->|"activates"| TGF_BETA

Outgoing (29)

Target	Relation	Type	Str
Angiogenesis	correlates_with	process	0.92
alpha-synuclein induced toxicity	mediates	process	0.85
PULMONARY HYPERTENSION	involved_in	entity	0.80
angiogenic properties	correlates_with	process	0.70
Als	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
APOE	inhibits	gene	0.60
Macrophage	inhibits	cell_type	0.60
Tgf-Beta	activates	pathway	0.60
IL-6	inhibits	gene	0.60
CANCER	associated_with	disease	0.58
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.44
COLORECTAL CANCER	activates	disease	0.30
COLORECTAL CANCER	associated_with	disease	0.30
METASTASIS	activates	process	0.30
METASTASIS	associated_with	process	0.30
FIBROSIS	activates	disease	0.30
CANCER	activates	disease	0.30
HEPATOCELLULAR CARCINOMA	activates	disease	0.30
AGING	regulates	process	0.30
EGFR	activates	gene	0.30
FERROPTOSIS	regulates	process	0.30
ROS	regulates	protein	0.30
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.30
AGING	activates	process	0.30
CYTOKINES	regulates	protein	0.30
STROKE	regulates	disease	0.30
NF-KB	interacts_with	gene	0.30
AUTOPHAGY	inhibits	process	0.30

Incoming (127)

Source	Relation	Type	Str
TREM2	regulated_by	gene	0.80
TNF	activates	gene	0.70
CYTOKINES	activates	gene	0.70
BMPR1B	participates_in	gene	0.70
CYTOKINES	regulates	gene	0.70
CANCER	regulates	gene	0.70
NGF	treats	gene	0.60
BMP2	interacts_with	gene	0.60
BMP4	interacts_with	gene	0.60
IL-6	regulates	gene	0.60
CANCER	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
P53	contributes_to	gene	0.60
INFLAMMATION	protects_against	gene	0.60
P53	protects_against	gene	0.60
Cancer	regulates	disease	0.60
Als	protects_against	disease	0.60
Inflammation	protects_against	disease	0.60
Longevity	protects_against	disease	0.60
FAS	treats	gene	0.60
EGF	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	activates	gene	0.60
BCL-2	treats	gene	0.60
6-OHDA	treats	gene	0.60
Tumor	activates	disease	0.60
Parkinson	activates	disease	0.60
Als	treats	disease	0.60
Cirrhosis	activates	disease	0.60
Hypertension	activates	disease	0.60
Fibrosis	activates	disease	0.60
TNF	regulates	gene	0.60
ABCD3	regulates	gene	0.60
APOE	inhibits	gene	0.60
APOPTOSIS	treats	gene	0.60
TGF-BETA	activates	gene	0.60
LRP1	activates	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
BCL-2	therapeutic_target	gene	0.60
Hepatocellular Carcinoma	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Carcinoma	therapeutic_target	disease	0.60
Hepatitis	therapeutic_target	disease	0.60
Autoimmune	therapeutic_target	disease	0.60
VEGF	activates	gene	0.60
IL-6	inhibits	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BBB leak induces secondary pericyte senescence through TGF-b	0.560	neurodegeneration	Does pericyte senescence drive BBB break
Early Postnatal TGF-beta Signaling Establishes Lifelong Regi	0.500	neuroinflammation	How do regional, age, and sex-dependent