gene 2,755 words KG: PICALM
Contents

PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein

🧬 Gene Info
Gene SymbolPICALM
Full NamePhosphatidylinositol Binding Clathrin Assembly Protein
Chromosome10q24.2
Functionis a gene located on chromosome 10q24.
Primary ExpressionBrain, Blood cells, Heart, Lung
Molecular Weight70 kDa
Amino Acids652 aa
Exons21
PathwaysAmyloid, Autophagy, Clathrin-mediated Endocytosis, Complement, Glucose Metabolism
UniProt IDQ7Z417
NCBI Gene ID81501
Ensembl IDENSG00000021762
OMIM610004
GeneCardsPICALM
Human Protein AtlasPICALM
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Cognitive Resilience
InteractionsABCA1, ABCA7, Actin, AD, AKT, ALZHEIMER
KG Connections491 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
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Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (14)

Alzheimer Indonesia
institution · KG edge: activates
ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ABCA1 co_discussed PICALM
APP co_discussed PICALM
BIN1 co_discussed PICALM
CD2AP co_discussed PICALM
CR1 co_discussed PICALM
GRN co_discussed PICALM
PICALM co_discussed PSEN1
PICALM co_discussed TREM2
SORL1 associated_with PICALM
PLD3 associated_with PICALM

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