| Gene Symbol | PICALM |
| Full Name | Phosphatidylinositol Binding Clathrin Assembly Protein |
| Chromosome | 10q24.2 |
| Function | is a gene located on chromosome 10q24. |
| Primary Expression | Brain, Blood cells, Heart, Lung |
| Subcellular Localization | of β-secretase (BACE1) and γ-secretase components. Enhanced endocytosis of these proteases typically reduces Aβ producti |
| Molecular Weight | 70 kDa |
| Amino Acids | 652 aa |
| Exons | 21 |
| Pathways | Amyloid, Autophagy, Clathrin-mediated Endocytosis, Complement, Glucose Metabolism |
| UniProt ID | Q7Z417 |
| NCBI Gene ID | 81501 |
| Ensembl ID | ENSG00000021762 |
| OMIM | 610004 |
| GeneCards | PICALM |
| Human Protein Atlas | PICALM |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Cognitive Resilience |
| Interactions | ABCA1, ABCA7, Actin, AD, AKT, ALZHEIMER |
| KG Connections | 490 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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