Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGC-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PGC |
| Function | Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | PGC |
| Human Protein Atlas | PGC |
| Interactions | AMPK |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
PGC_1(["PGC-1"])
PGC_1_(["PGC-1Alpha"])
AMPK(["AMPK"])
EPIGENETIC("EPIGENETIC")
RAPAMYCIN("RAPAMYCIN")
PEROXISOME("PEROXISOME")
MEF2C(["MEF2C"])
NEURON(["NEURON"])
Pi3K["Pi3K"]
mTOR["mTOR"]
PGC_1 -->|"co discussed"| PGC_1_
PGC_1 -->|"activates"| AMPK
PGC_1 -->|"activates"| EPIGENETIC
PGC_1 -->|"activates"| RAPAMYCIN
PGC_1 -->|"activates"| PEROXISOME
MEF2C -->|"co discussed"| PGC_1
NEURON -->|"co discussed"| PGC_1
Pi3K -->|"activates"| PGC_1
mTOR -->|"activates"| PGC_1
style PGC_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| PGC-1Α | co_discussed | protein | 0.50 |
| AMPK | activates | protein | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| PEROXISOME | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil | 0.778 | neurodegeneration | Gut Microbiome Analysis in Parkinson's D |
| APOE4 drives astrocyte metabolic reprogramming toward glycol | 0.580 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mito | 0.520 | neurodegeneration | What are the optimal oxygen pressure, du |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PGC-1α knockout analysis of PV+ interneuron maturation | validation | neurodevelopmental disorders | 0.850 | 0.00 | knockout mice | proposed | N/A |
| PV+ interneuron subtype diversification analysis | exploratory | neurodevelopmental disorders | 0.750 | 0.00 | mouse cortical PV+ interneuron | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PGC-1 in their description or question text
No additional research found