SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
redirect 629 words KG: PGC-1α
Contents

PGC-1α Protein

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (9)

Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (9)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (15)

GWAS meta-analysis of major depressive disorder across three
exploratory · proposed · Score: 0.95PGC-1α knockout effects on PV+ interneuron maturation
validation · proposed · Score: 0.90Differential GWAS of schizophrenia vs PTSD
exploratory · proposed · Score: 0.90TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85PGC-1α knockout analysis of PV+ interneuron maturation
validation · proposed · Score: 0.85

See Also (15)

NeuRon Therapeutics
company · KG edge: co_discussedNeuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: inhibitsNeurodegeneration
disease · KG edge: associated_withAMPK (AMP-Activated Protein Kinase)
entity · KG edge: regulatesMitochondria
entity · KG edge: activates

Knowledge Graph (12 edges)

AMPK regulates PGC-1α
PGC-1α activates SIRT3
AMPK activates PGC-1α
PPAR-γ interacts_with PGC-1α
PGC-1α regulates MFN2
PGC-1α expressed_in Schwann cells
PGC-1α regulates mitochondrial biogenesis
PGC-1α activates ULK1
PGC-1α activates mitophagy
PGC-1α inhibits NLRP3

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas