concept

PD-1/PD-L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PD-1/PD-L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

1Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PD-1/PD-L1
Key Genes/Proteins	DLL4, GLIOBLASTOMA, LRP1, NOTCH2
Related Diseases	Glioma, TUMOR
Related Pathways	Immune Checkpoint, NOTCH

Wiki Pages (1)

Knowledge base pages for this entity

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

mechanism · 3120 words

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Pathway Diagram

graph TD
    PD_1_PD_L1["PD-1/PD-L1"]
    CANCER["CANCER"] -->|"target for"| PD_1_PD_L1
    Cancer["Cancer"] -->|"target for"| PD_1_PD_L1
    Als["Als"] -->|"target for"| PD_1_PD_L1
    Tumor["Tumor"] -->|"inhibits"| PD_1_PD_L1
    DNA["DNA"] -->|"target for"| PD_1_PD_L1
    AKT["AKT"] -->|"inhibits"| PD_1_PD_L1
    PI3K["PI3K"] -->|"inhibits"| PD_1_PD_L1
    MTOR["MTOR"] -->|"inhibits"| PD_1_PD_L1

Outgoing (1)

Target	Relation	Type	Str
PD-L1	inhibits	concept	0.50

Incoming (53)

Source	Relation	Type	Str
Cancer	therapeutic_target	disease	0.90
CANCER	therapeutic_target	gene	0.90
Als	therapeutic_target	disease	0.80
DNA	therapeutic_target	gene	0.70
CANCER	regulates	gene	0.70
Cancer	regulates	disease	0.70
Tumor	inhibits	disease	0.70
PI3K	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
VEGF	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
Als	inhibits	disease	0.60
NAD	contributes_to	gene	0.60
KRAS	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60
Colorectal Cancer	therapeutic_target	disease	0.60
Gastric Cancer	therapeutic_target	disease	0.60
GAIN	therapeutic_target	gene	0.60
MDM2	therapeutic_target	gene	0.60
CXCL10	activates	gene	0.60
CD8	activates	gene	0.60
Tumor	regulates	disease	0.60
Infection	regulates	disease	0.60
Inflammation	regulates	disease	0.60
CANCER	associated_with	gene	0.60
Tumor	activates	disease	0.60
Cancer	associated_with	disease	0.60
INFLAMMATION	regulates	gene	0.60
Lung Cancer	associated_with	disease	0.60
NF-ΚB	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
Tumor	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
APOPTOSIS	therapeutic_target	gene	0.60
P53	inhibits	gene	0.60
AKT	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NOTCH	inhibits	pathway	0.50
Macrophage	inhibits	cell_type	0.50
microglia	inhibits	cell_type	0.50
TUMOR	inhibits	disease	0.50
GLIOBLASTOMA	inhibits	gene	0.50
MACROPHAGES	inhibits	concept	0.50
Glioma	inhibits	disease	0.50
Tumor Microenvironment	inhibits	process	0.50
Immune Checkpoint	inhibits	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PD-1/PD-L1 in their description or question text

No additional research found