gene

FH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

17Outgoing

0Incoming

0Experiments

0Debates

Summary

FH Gene

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🧬 Gene Info

Gene Symbol	FH
Function	The FH gene encodes Fumarate Hydratase Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Ensembl ID	ENSG00000091426
GeneCards	FH
Human Protein Atlas	FH
Associated Diseases	Alzheimer's disease, Kidney Cancer
Interactions	LDLR, PTX3
KG Connections	17 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FH["FH"]
    Kidney_Cancer["Kidney Cancer"]
    FH ==>|"causes"| Kidney_Cancer
    LDLR["LDLR"]
    FH -->|"interacts with"| LDLR
    endothelial_cells["endothelial cells"]
    FH -->|"expressed in"| endothelial_cells
    neurodegeneration["neurodegeneration"]
    FH -->|"implicated in"| neurodegeneration
    style FH fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (17)

Target	Relation	Type	Str
Kidney Cancer	causes	disease	0.80
endothelial cells	expressed_in	cell_type	0.60
PTX3	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
LDL	causes	gene	0.60
Alzheimer's disease	causes	disease	0.60
LDLR	interacts_with	gene	0.60
LDLR	associated_with	gene	0.60
LDLR	causes	gene	0.60
GBA1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
P300	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FH in their description or question text

No additional research found

FH

Understanding Entity Pages

Summary

Wiki Pages (8)

FH Gene

FHL1 Gene

NEFH Protein

NEFH — Neurofilament Heavy Chain

CFH

FHL1 Protein

NEFH Gene

Neurofilament Heavy Chain (NFH)