entity

Aβ42

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Aβ42: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

1Hypotheses

4Analyses

11Outgoing

5Incoming

0Experiments

5Debates

No AI portrait yet

Outgoing (11)

Target	Relation	Type	Str
Amyloid plaque	promotes	phenotype	0.90
V-ATPase	inhibits	protein	0.90
lysosomal acidification	impairs	process	0.90
Alzheimer's Disease	risk_factor_for	disease	0.85
Neurogenesis	modulates	process	0.85
Alzheimer's disease	biomarker_for	disease	0.80
V-ATPase function	inhibits	mechanism	0.70
V-ATPase	binds	protein	0.70
neurodegeneration	associated_with	disease	0.70
Aβ40	causes	protein	0.70
circPDS5B downregulation	causes	process	0.50

Incoming (5)

Source	Relation	Type	Str
Microglia	associated_with	cell_type	0.95
Macrophages	associated_with	cell_type	0.95
PSEN1	increases	gene	0.80
CD33	regulates	gene	0.60
33278887	trended toward an inverse relationship with	paper	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s

Mentioning Analyses (4)

Scientific analyses that reference this entity

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 3 hypotheses Top: 0.595

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 3 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

The observation that salsalate and diflunisal decrease both AD and TBI incidence

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Protein aggregation cross-seeding across neurodegenerative diseases?

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.53 · 2026-04-06

Related Research

Hypotheses and analyses mentioning Aβ42 in their description or question text

No additional research found