concept

NF-KB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-KB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1632Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

NF-KB is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 482 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NF-KB
Key Genes/Proteins	ABCA7, ABLIM1, ACETYLCHOLINE, ACHE, Actin, ACVR1
Related Diseases	Aging
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

nf-kb

general · 1939 words

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Pathway Diagram

flowchart TD
    NF_KB(["NF-KB"])
    Nf_Kb["Nf-Kb"]
    Inflammation["Inflammation"]
    TNF__(["TNF-Alpha"])
    TNF(["TNF"])
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    APOPTOSIS(["APOPTOSIS"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    MICROGLIA["MICROGLIA"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AKT(["AKT"])
    CANCER(["CANCER"])

    NF_KB -->|"activates"| Nf_Kb
    NF_KB -->|"activates"| Inflammation
    NF_KB -->|"activates"| TNF__
    NF_KB -->|"associated with"| TNF
    NF_KB -->|"associated with"| PARKINSON_S_DISEASE
    NF_KB -->|"associated with"| OXIDATIVE_STRESS
    TNF -->|"activates"| NF_KB
    APOPTOSIS -->|"associated with"| NF_KB
    NEURODEGENERATION -->|"associated with"| NF_KB
    MICROGLIA -->|"associated with"| NF_KB
    NEUROINFLAMMATION -->|"associated with"| NF_KB
    ALZHEIMER_S_DISEASE -->|"associated with"| NF_KB
    AKT -->|"associated with"| NF_KB
    NF_KB -->|"regulates"| Nf_Kb
    NF_KB -->|"activates"| CANCER

    style NF_KB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (736)

Target	Relation	Type	Str
PI3K	associated_with	gene	1.00
MACROPHAGE	associated_with	cell_type	1.00
HIPPOCAMPUS	associated_with	brain_region	1.00
Nf-Kb	activates	pathway	1.00
TNF	associated_with	gene	1.00
NLRP3	associated_with	gene	1.00
Inflammation	activates	disease	1.00
TNF-Α	activates	gene	1.00
MULTIPLE SCLEROSIS	associated_with	disease	1.00
TLR4	associated_with	gene	1.00
NEURON	associated_with	cell_type	1.00
CORTEX	associated_with	brain_region	1.00
MAPK	associated_with	gene	1.00
h-35cc314907	targeted_by	hypothesis	1.00
TAU	associated_with	protein	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
NRF2	associated_with	gene	1.00
Nf-Kb	regulates	pathway	1.00
CANCER	activates	gene	1.00
DEMENTIA	associated_with	disease	0.98
GFAP	associated_with	protein	0.98
C3	associated_with	gene	0.98
JAK	associated_with	gene	0.98
INOS	associated_with	gene	0.96
Inflammation	regulates	disease	0.95
Alzheimer's Disease	involved_in	disease	0.95
Cancer	activates	disease	0.95
Neuroinflammation	activates	disease	0.95
CCL20	regulates	protein	0.90
SIRT1	inhibits	protein	0.90
IL6	regulates	protein	0.90
Alzheimer's disease	fuels	disease	0.90
Inflammation	regulates	process	0.90
Cancer	associated_with	disease	0.90
ST6GAL1	regulates	gene	0.90
NLRP3	activates	protein	0.90
STAT3	interacts_with	pathway	0.90
UBIQUITIN	associated_with	protein	0.90
p62/SQSTM1	regulates	protein	0.90
STROKE	associated_with	disease	0.90
Neurodegeneration	associated_with	process	0.90
SIRT1	associated_with	gene	0.90
DEPRESSION	associated_with	disease	0.90
STAT3	associated_with	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
Nf-Kb	inhibits	pathway	0.90
INFLAMMATION	regulates	gene	0.90
NEURON	inhibits	cell_type	0.86
NEURON	activates	cell_type	0.86
NEURON	interacts_with	cell_type	0.86

Incoming (896)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMPK	associated_with	gene	1.00
IL-1B	associated_with	gene	1.00
CASP3	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
AKT	associated_with	gene	1.00
MTOR	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
TNF	activates	gene	1.00
NF-KB	activates	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
APOPTOSIS	associated_with	gene	1.00
TNF	activates	gene	1.00
TNF-Α	activates	gene	1.00
IL-6	associated_with	gene	1.00
ERK	associated_with	gene	1.00
h-35cc314907	targets	hypothesis	1.00
NEURODEGENERATION	associated_with	gene	1.00
NF-KB	regulates	gene	1.00
Inflammation	regulates	disease	1.00
CYTOKINES	activates	gene	1.00
Inflammation	activates	disease	1.00
B CELLS	activates	cell_type	0.95
MACROPHAGES	activates	cell_type	0.95
ABLIM1	activates	protein	0.95
TNIP1	inhibits	protein	0.90
SIRT1	inhibits	protein	0.90
IL-1β	activates	protein	0.90
ginseng root extract	inhibits	drug	0.90
hesperetin	inhibits	drug	0.90
ALS	associated_with	disease	0.90
P38	regulates	gene	0.90
TLR4	activates	protein	0.90
Cancer	activates	disease	0.90
NF-KB	inhibits	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
Neuroinflammation	activates	disease	0.90
INFLAMMATION	regulates	gene	0.90
CANCER	activates	gene	0.90
NEURON	activates	cell_type	0.86
Curcumin	modulates	compound	0.85
Astrocytes	expressed_in	cell_type	0.85
Reactive Microglia	expressed_in	cell_type	0.85
APOE	associated_with	gene	0.82
BAX	associated_with	gene	0.82
JUN	associated_with	gene	0.82
APP	associated_with	gene	0.80
PLEKHG5	activates	gene	0.80
miR-93-5p	activates	entity	0.80
LL37	modulates	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which microglial senescence contributes to ALS pathol

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.776

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate how microglial senescence drives ALS progression through inflammatio

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the mechanisms by which microglial senescence contributes to ALS pathol

closed · Rounds: 6 · Score: 0.75 · 2026-04-26

Related Research

Hypotheses and analyses mentioning NF-KB in their description or question text

No additional research found