gene

HAPLN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HAPLN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

0Experiments

0Debates

Summary

Extracellular matrix protein critical for perineuronal net formation and synaptic plasticity

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🧬 Gene Info

Gene Symbol	HAPLN4
Function	encodes a member of the hyaluronan and proteoglycan link protein (HAPLN) family.
Amino Acids	402 aa
Pathways	MAPK pathway
Ensembl ID	ENSG00000166920
GeneCards	HAPLN4
Human Protein Atlas	HAPLN4
HAPLN4 (BRAL1)	brain-specific
N-terminal domain	Hyaluronan-binding region
Core protein	Link protein core
C-terminal domain	Proteoglycan-binding region
Signal peptide	N-terminal targeting sequence (~20 aa)
Link module	Conserved hyaluronan-binding domain (~100 aa)
Core region	Variable length (~250 aa)
C-terminal region	Proteoglycan interaction sites
Associated Diseases	Alzheimer's disease, Schizophrenia, Epilepsy
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HAPLN4 Gene (Hyaluronan and Proteoglycan Link Protein 4)

gene · 1014 words

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Pathway Diagram

graph TD
    HAPLN4["HAPLN4"]
    GABAergic_synapses["GABAergic synapses"]
    HAPLN4 -->|"regulates"| GABAergic_synapses
    perineuronal_nets["perineuronal nets"]
    HAPLN4 -->|"component of"| perineuronal_nets
    extracellular_matrix["extracellular matrix"]
    HAPLN4 -->|"participates in"| extracellular_matrix
    MAPK_pathway(["MAPK pathway"])
    HAPLN4 -->|"interacts with"| MAPK_pathway
    neurodegeneration["neurodegeneration"]
    HAPLN4 -->|"implicated in"| neurodegeneration
    style HAPLN4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
GABAergic synapses	regulates	biological_process	0.80
perineuronal nets	component_of	biological_process	0.80
Deep cerebellar nuclei neurons	expressed_in	cell_type	0.80
Extracellular matrix	participates_in	biological_process	0.80
Purkinje cells	expressed_in	cell_type	0.70
Fast-signaling synapses	regulates	biological_process	0.70
extracellular matrix	participates_in	biological_process	0.70
MAPK pathway	interacts_with	pathway	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HAPLN4 in their description or question text

No additional research found