gene

MARK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MARK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

48Outgoing

34Incoming

0Experiments

0Debates

Summary

MARK4 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, implicated in. Associated with Als, Breast Cancer, Cancer. Connected to 25 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MARK4
Full Name	Microtubule Affinity Regulating Kinase 4
Chromosome	19q13.32
Protein Type	Kinase
Function	MARK4 is a serine/threonine-protein kinase that belongs to the CAMK (Ca²⁺/calmodulin-dependent protein kinase) group and AMPK-related kinase family.
Primary Expression	the brain and is involved in regulating microtubule stability through tau phosphorylation
Subcellular Localization	Cytoplasmic, associated with microtubules
Molecular Weight	76 kDa
Amino Acids	659 aa
Pathways	AMPK, AMPK signaling
UniProt ID	Q96GX8
NCBI Gene ID	57731
Ensembl ID	ENSG00000165548
OMIM	608285
GeneCards	MARK4
Human Protein Atlas	MARK4
Associated Diseases	Alzheimer, Alzheimer's disease, neuroinflammation
Interactions	AGTR1, AND, APOPTOSIS, ATP, CANCER, C-MYC
KG Connections	82 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MARK4 — AlphaFold Q96GX8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MARK4 Gene

gene · 643 words

→

MARK4 Protein (Microtubule Affinity Regulating Kinase 4)

protein · 1536 words

→

Pathway Diagram

graph TD
    MARK4["MARK4"]
    Als{"Als"}
    MARK4 -->|"activates"| Als
    Cancer{"Cancer"}
    MARK4 -->|"activates"| Cancer
    Tumor{"Tumor"}
    MARK4 -->|"activates"| Tumor
    KAT2A["KAT2A"]
    MARK4 -->|"activates"| KAT2A
    YAP["YAP"]
    MARK4 -->|"activates"| YAP
    Tgf__(["Tgf-Beta"])
    MARK4 -->|"activates"| Tgf__
    HIPPO["HIPPO"]
    MARK4 -->|"activates"| HIPPO
    neurodegeneration["neurodegeneration"]
    MARK4 -->|"implicated in"| neurodegeneration
    HIPPO -->|"activates"| MARK4
    MYC["MYC"]
    MYC -->|"activates"| MARK4
    CANCER["CANCER"]
    CANCER -->|"activates"| MARK4
    AND["AND"]
    AND -->|"activates"| MARK4
    style MARK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
Myocardial Contractility	regulates	phenotype	0.90
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Myocardial Infarction	activates	disease	0.65
Cardiac	activates	disease	0.65
Cancer	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ataxia	therapeutic_target	disease	0.65
Apoptosis	therapeutic_target	pathway	0.60
Angiogenesis	therapeutic_target	pathway	0.60
Microrna	therapeutic_target	pathway	0.60
Amyloid	therapeutic_target	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
MICRORNAS	therapeutic_target	gene	0.60
Angiogenesis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
AGTR1	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MICRORNAS	activates	gene	0.60
GENES	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
KAT2A	activates	gene	0.60
MYC	activates	gene	0.60
NLRP3	activates	gene	0.60
NLRP3	inhibits	gene	0.60
NLRP3	implicated_in	gene	0.60
neuroinflammation	activates	disease	0.60
neuroinflammation	implicated_in	disease	0.60
YAP	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
HIPPO	activates	gene	0.60
CANCER	activates	gene	0.60
Metastasis	activates	pathway	0.60
Invasion	activates	pathway	0.60
Tgf-Β Signaling	activates	pathway	0.60
Alzheimer's disease	implicated_in	disease	0.60
AND	activates	gene	0.60
microglia	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (34)

Source	Relation	Type	Str
miR-199a-5p	targets	biomarker	0.95
APOPTOSIS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
C-MYC	activates	gene	0.60
YAP	activates	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
MICRORNAS	activates	gene	0.60
ATP	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
GSK3	associated_with	gene	0.60
HIPPO	activates	gene	0.60
CANCER	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
HUNTINGTON'S DISEASE	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALS	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
CDK5	associated_with	gene	0.60
AGTR1	activates	gene	0.60
MYC	activates	gene	0.60
KAT2A	activates	gene	0.60
TAU	associated_with	gene	0.60
HUNTINGTIN	therapeutic_target	gene	0.60
LRRK2	therapeutic_target	gene	0.60
PINK1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MARK4 in their description or question text

No additional research found