protein 2,294 words KG: LRPPRC
Contents

LRPPRC Protein

🔬 Protein Info
Gene SymbolLRPPRC
Chromosome2p21
FunctionLRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression.
Subcellular Localization</strong></td><td>Mitochondria</td></tr>
Molecular Weight156 kDa
Amino Acids394 aa
Exons38
PathwaysOxidative Phosphorylation
Ensembl IDENSG00000138095
GeneCardsLRPPRC
Human Protein AtlasLRPPRC
Associated DiseasesAls, Parkinson
Known Drugs/Compoundsdonepezil, Donepezil, Duloxetine
InteractionsACO2, Actin, AND, ATP, AUTOPHAGY, BECN1
KG Connections105 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: therapeutic_target
Donepezil
entity · KG edge: binds
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Genes
index · KG edge: therapeutic_target
ACO2 — Aconitase 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

NS1 interacts_with LRPPRC
LRPPRC interacts_with BECN1
VDAC1 therapeutic_target LRPPRC
HSPA9 therapeutic_target LRPPRC
CYCS therapeutic_target LRPPRC
ACO2 therapeutic_target LRPPRC
GLUD1 associated_with LRPPRC
SNCA therapeutic_target LRPPRC
LRPPRC associated_with NDUFS2
LRPPRC associated_with NDUFS1

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