gene 1,293 words KG: LRPPRC
Contents

LRPPRC — Leucine-Rich Pentatricopeptide Repeat Containing

🧬 Gene Info
Gene SymbolLRPPRC
Full NameLeucine-Rich Pentatricopeptide Repeat Containing
Chromosome2p21
FunctionLRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression.
Molecular Weight156 kDa
Amino Acids394 aa
Exons38
PathwaysOxidative Phosphorylation
Ensembl IDENSG00000138095
GeneCardsLRPPRC
Human Protein AtlasLRPPRC
Associated DiseasesAls, Parkinson
Known Drugs/Compoundsdonepezil, Donepezil, Duloxetine
InteractionsACO2, Actin, AND, ATP, AUTOPHAGY, BECN1
SciDEX HypothesesMitochondrial RNA Processing Enhancement
KG Connections105 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Donepezil
entity · KG edge: binds
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Genes
index · KG edge: therapeutic_target
ACO2 — Aconitase 2
gene · KG edge: activates

Knowledge Graph (12 edges)

NS1 interacts_with LRPPRC
LRPPRC interacts_with BECN1
VDAC1 therapeutic_target LRPPRC
HSPA9 therapeutic_target LRPPRC
CYCS therapeutic_target LRPPRC
ACO2 therapeutic_target LRPPRC
GLUD1 associated_with LRPPRC
SNCA therapeutic_target LRPPRC
LRPPRC associated_with NDUFS2
LRPPRC associated_with NDUFS1

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