Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VALPROATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | VALPROATE |
| Key Genes/Proteins | CHRNA7 |
| Related Diseases | DNA METHYLATION, FERROPTOSIS |
graph TD
VALPROATE[VALPROATE]
VALPROATE -->|risk_factor_for| Major_Congenital_Malformations[Major Congenital Malformations]
VALPROATE -->|produces| NEURONS[NEURONS]
VALPROATE -->|modifies| INTERNEURONS[INTERNEURONS]
FERROPTOSIS[FERROPTOSIS] -->|activates| VALPROATE
CHRNA7[CHRNA7] -->|regulates| VALPROATE| Target | Relation | Type | Str |
|---|---|---|---|
| Major Congenital Malformations | risk_factor_for | phenotype | 0.95 |
| Major Congenital Malformations | correlates_with | phenotype | 0.90 |
| NEURONS | associated_with | cell_type | 0.65 |
| INTERNEURONS | modifies | cell_type | 0.65 |
| NEURON | associated_with | cell_type | 0.50 |
| STRIATUM | associated_with | brain_region | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| CHRNA7 | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FERROPTOSIS | activates | phenotype | 0.70 |
| CHRNA7 | regulates | gene | 0.65 |
| FERROPTOSIS | associated_with | phenotype | 0.50 |
| INTERNEURONS | associated_with | cell_type | 0.50 |
| CORTEX | associated_with | brain_region | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| STRIATUM | associated_with | brain_region | 0.45 |
| CARBAMAZEPINE | associated_with | drug | 0.45 |
| LAMOTRIGINE | associated_with | drug | 0.45 |
| DNA METHYLATION | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VALPROATE in their description or question text
No additional research found