gene

arnt2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arnt2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

25Outgoing

4Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARNT2
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator 2
Aliases	ARNT2 gene
Chromosome	15q21.3
Function	encodes a critical bHLH-PAS (basic Helix-Loop-Helix-Period Arnt-Single-minded) domain transcription factor that serves as a shared partner for multiple hypoxia-sensitive and circadian rhythm regula...
Molecular Weight	79 kDa
Amino Acids	710 aa
Exons	24
UniProt ID	Q9W2E6
NCBI Gene ID	10638
Ensembl ID	ENSG00000150457
OMIM	606994
GeneCards	ARNT2
Human Protein Atlas	ARNT2
bHLH Domain (aa 1-60)	Basic region for DNA binding and helix-loop-helix for protein dimerization
Associated Diseases	neurodegeneration
KG Connections	3 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: arnt2 — AlphaFold Q9W2E6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

gene · 1761 words

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Pathway Diagram

graph TD
    ARNT2["ARNT2"]
    ARNT2 -->|"target for"| Cancer["Cancer"]
    ARNT2 -->|"expressed in"| SST["SST"]
    ARNT2 -->|"regulates"| Interneuron["Interneuron"]
    ARNT2 -->|"regulates"| Neuron["Neuron"]
    ARNT2 -->|"activates"| Pyramidal["Pyramidal"]
    ARNT2 -->|"regulates"| AND["AND"]
    ARNT2 -->|"inhibits"| ACC["ACC"]
    SST -->|"activates"| ARNT2
    ACC -->|"inhibits"| ARNT2

Outgoing (25)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARNT2	data_in	dataset_row	0.00
Cancer	therapeutic_target	disease	0.65
AND	regulates	gene	0.60
ACC	inhibits	gene	0.60
MITF	transports	gene	0.60
Neuron	regulates	cell_type	0.60
SST	expressed_in	cell_type	0.60
Pyramidal	activates	cell_type	0.60
SST	activates	gene	0.60
Rb	regulates	protein	0.60
NCOR1	transports	gene	0.60
TCF7L2	transports	gene	0.60
Interneuron	regulates	cell_type	0.60
App	regulates	protein	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
neurons	expressed_in	cell_type	0.60
Cortex	expressed_in	brain_region	0.55
Interneuron	expressed_in	cell_type	0.55
Pyramidal Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
INTERNEURONS	activates	concept	0.50
INTERNEURONS	regulates	concept	0.50
Cortex	inhibits	brain_region	0.50

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARNT2	data_in	dataset_row	0.00
ACC	expressed_in	gene	0.60
ACC	inhibits	gene	0.60
SST	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arnt2 in their description or question text

No additional research found