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gene 1,853 words KG: IL6ST
Contents

IL6ST - Interleukin 6 Signal Transducer (gp130)

🧬 Gene Info
Gene SymbolIL6ST
Full NameInterleukin 6 Signal Transducer (gp130)
Aliasesgp130
Chromosome5q11.2
Primary ExpressionUbiquitous (neurons, astrocytes, microglia, oligodendrocytes)
Molecular Weight130 kDa
Amino Acids917 aa
Exons18
PathwaysEpigenetic, Notch
UniProt IDP40189
NCBI Gene ID3572
GeneCardsIL6ST
Human Protein AtlasIL6ST
Associated Diseasesneurodegeneration
InteractionsAND, APOPTOSIS, CANCER, CREBBP, CYTOKINES, FERROPTOSIS
KG Connections64 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (5)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Oligodendrocyte White Matter Vulnerability
Score: 0.65Vagal Afferent Microbial Signal Modulation
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.58Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (2)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_withIL6 (Redirect)
redirect · KG edge: interacts_withastrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: regulatesEpigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: regulatesGenes
index · KG edge: regulates

Knowledge Graph (12 edges)

α-synuclein activates IL6ST
IL6 interacts_with IL6ST
RAGE therapeutic_target IL6ST
IL6R interacts_with IL6ST
LRP1 interacts_with IL6ST
NR3C1 interacts_with IL6ST
GATA1 interacts_with IL6ST
MYC interacts_with IL6ST
CREBBP interacts_with IL6ST
STAT3 activates IL6ST

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