| Gene Symbol | GSDME |
| Full Name | Gasdermin E |
| Aliases | Gasdermin E/DFNA5 |
| Chromosome | 7p15.3 |
| Function | Caspase-3 cleavage: Unlike GSDMD, GSDME is cleaved by executioner caspase-3 |
| Primary Expression | cochlea, brain, and other tissues |
| Molecular Weight | 55 kDa |
| Amino Acids | 496 aa |
| Exons | 12 |
| Pathways | Pyroptosis |
| UniProt ID | [O60443](https://www.uniprot.org/uniprotkb/O60443) |
| GeneCards | GSDME |
| Human Protein Atlas | GSDME |
| N-terminal domain (residues 1-275) | The pore-forming region. This domain is auto-inhibited by the C-terminal domain in the full-length protein but becomes capable of oligomerizing into pores (10-20 nm diameter) upon cleavage[@xia2021]. |
| C-terminal domain (residues 276-496) | The regulatory region that maintains the protein in an inactive conformation. C-terminal domain removal is both necessary and sufficient for pore formation. |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Axon Loss, Cancer, Frontotemporal Dementia, Melanoma, Pyroptosis |
| Known Drugs/Compounds | Celastrol, XHP |
| Interactions | AKT, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND |
| KG Connections | 260 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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