| Gene Symbol | GEMIN3 |
| Aliases | GEMIN3/DDX20 gene in ALS |
| Function | GEMIN3 (Gem Nuclear Organelle Associated Protein 3), also known as DDX20 (DEAD-Box Helicase 20), is a member of the DEAD-box RNA helicase family and a core component of the SMN complex. |
| Ensembl ID | ENSG00000089356 |
| GeneCards | GEMIN3 |
| Human Protein Atlas | GEMIN3 |
| RNA Helicase Activity | Unwinds RNA duplexes in an ATP-dependent manner |
| ATPase Activity | Uses ATP hydrolysis to power conformational changes |
| RNA Binding | Binds various RNA species including snRNA, miRNA, and mRNA |
| Spliceosomal snRNP Assembly | Facilitates proper assembly of the SMN complex with snRNA |
| miRNA Biogenesis | Involved in microRNA processing through interaction with the microprocessor complex |
| Transcriptional Regulation | Modulates gene expression through interactions with transcription factors |
| DEAD box motif | Characteristic sequence of DEAD-box helicases |
| RNA binding | Binds single-stranded RNA |
| Unwinding activity | Separates RNA duplexes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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