gene

NTN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

35Outgoing

14Incoming

0Experiments

0Debates

Summary

NTN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with AD, ALI, ALS. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTN3
Full Name	Netrin 3
Chromosome	16p13.3
Protein Type	Receptor
Function	Like other netrins, NTN3 exerts its effects through binding to two main receptor families
Primary Expression	the adult brain and may have roles in synaptic plasticity and repair
Molecular Weight	71 kDa
Amino Acids	641 aa
UniProt ID	Q9Y2I2
NCBI Gene ID	4904
Ensembl ID	ENSG00000118445
OMIM	603389
GeneCards	NTN3
Human Protein Atlas	NTN3
N-terminal domain	Contains laminin-like domains (VI and V) that mediate receptor binding
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease, disease
Interactions	AMYLOID, AND, DNA, NTN1, Proteins, PTN
KG Connections	49 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTN3 — AlphaFold Q9Y2I2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTN3["NTN3"]
    Alzheimer{"Alzheimer"}
    NTN3 -->|"expressed in"| Alzheimer
    Als{"Als"}
    NTN3 -->|"expressed in"| Als
    NTN3 -->|"associated with"| Als
    NTN3 -->|"associated with"| Alzheimer
    ALS{"ALS"}
    NTN3 -->|"expressed in"| ALS
    Endocytosis(["Endocytosis"])
    NTN3 -->|"expressed in"| Endocytosis
    Complement(["Complement"])
    NTN3 -->|"expressed in"| Complement
    Exocytosis(["Exocytosis"])
    NTN3 -->|"expressed in"| Exocytosis
    SNRNP70["SNRNP70"]
    NTN3 -->|"interacts with"| SNRNP70
    TARDBP["TARDBP"]
    NTN3 -->|"interacts with"| TARDBP
    Amyloid(["Amyloid"])
    NTN3 -->|"interacts with"| Amyloid
    NTN3 -->|"associated with"| Complement
    TARDBP -->|"interacts with"| NTN3
    NTN1["NTN1"]
    NTN1 -->|"interacts with"| NTN3
    SNRNP70 -->|"interacts with"| NTN3
    JUN["JUN"]
    JUN -->|"expressed in"| NTN3
    DNA["DNA"]
    DNA -->|"interacts with"| NTN3
    JUN -->|"associated with"| NTN3
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"expressed in"| NTN3
    PTN["PTN"]
    PTN -->|"interacts with"| NTN3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"interacts with"| NTN3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| NTN3
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"expressed in"| NTN3
    TAU["TAU"]
    TAU -->|"interacts with"| NTN3
    style NTN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

Target	Relation	Type	Str
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyloid	interacts_with	pathway	0.60
Complement	associated_with	pathway	0.60
Endocytosis	associated_with	pathway	0.60
Exocytosis	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Endocytosis	expressed_in	pathway	0.60
Complement	expressed_in	pathway	0.60
Exocytosis	expressed_in	pathway	0.60
TAU	interacts_with	gene	0.60
Protein Aggregation	expressed_in	pathway	0.60
Rb	interacts_with	protein	0.60
SNRNP70	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
PTN	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
TAR	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AMYLOID	interacts_with	gene	0.60
JUN	expressed_in	gene	0.60
Alzheimer	implicated_in	disease	0.50
Alzheimer's disease	implicated_in	disease	0.50
ILD	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
disease	implicated_in	disease	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-β	interacts_with	concept	0.50
AD	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50
Als	implicated_in	disease	0.50

Incoming (14)

Source	Relation	Type	Str
TARDBP	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
SNRNP70	interacts_with	gene	0.60
JUN	expressed_in	gene	0.60
JUN	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
AND	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
PTN	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
TAU	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity