gene

RAB39B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB39B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

14Outgoing

12Incoming

0Experiments

0Debates

Summary

RAB39B is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Als, Autism, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB39B
Full Name	RAB39B, Member RAS Oncogene Family
Function	1. Early endosome dynamics: Regulates cargo sorting and recycling from early endosomes
Primary Expression	the brain, with highest levels in the substantia nigra, hippocampus, and cerebral cortex
Molecular Weight	26 kDa
Amino Acids	235 aa
Exons	8
GeneCards	RAB39B
Human Protein Atlas	RAB39B
Associated Diseases	Als, Autism, Ms, Parkinson, Parkinson's disease
Interactions	C9ORF72, PI3K
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB39B["RAB39B"]
    Parkinson{"Parkinson"}
    RAB39B -->|"associated with"| Parkinson
    Als{"Als"}
    RAB39B -->|"associated with"| Als
    Ms{"Ms"}
    RAB39B -->|"associated with"| Ms
    Autism{"Autism"}
    RAB39B -->|"associated with"| Autism
    PI3K["PI3K"]
    RAB39B -->|"interacts with"| PI3K
    AKT["AKT"]
    RAB39B -->|"associated with"| AKT
    AUTOPHAGY["AUTOPHAGY"]
    RAB39B -->|"associated with"| AUTOPHAGY
    C9ORF72["C9ORF72"]
    RAB39B -->|"interacts with"| C9ORF72
    Autophagy(["Autophagy"])
    RAB39B -->|"associated with"| Autophagy
    Akt(["Akt"])
    RAB39B -->|"associated with"| Akt
    Pi3K(["Pi3K"])
    RAB39B -->|"interacts with"| Pi3K
    neurodegeneration["neurodegeneration"]
    RAB39B -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| RAB39B
    style RAB39B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Autism	associated_with	disease	0.65
AUTOPHAGY	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
Autophagy	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60
PI3K	interacts_with	gene	0.60
AKT	associated_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
SNCA	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60

Incoming (12)

Source	Relation	Type	Str
ATP13A2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
GBA	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AND	associated_with	gene	0.60
PI3K	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB39B in their description or question text

No additional research found