| Gene Symbol | CTSSPROTEIN |
| Full Name | Cathepsin S - CTSS |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | ~22 kDa (proenzyme), ~18 kDa (mature enzyme) |
| UniProt ID | Search UniProt |
| GeneCards | CTSSPROTEIN |
| Human Protein Atlas | CTSSPROTEIN |
| Structure | Papain-like fold with two domains forming a catalytic cleft |
| Active Site | Cys139, His299, Asn319 form the catalytic triad |
| pH Stability | Active at neutral pH |
| Secretion | Can be released from activated macrophages and microglia |
| ECM Remodeling | Degrades extracellular matrix proteins |
| Antigen Presentation | Essential for MHC class II antigen processing [3] |
| Associated Diseases | Aging |
| Interactions | AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, APP/PS1 |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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