gene 1,679 words KG: CTSS
Contents

CTSS — Cathepsin S

🧬 Gene Info
Gene SymbolCTSS
Full NameCathepsin S
Chromosome1q21.3
Protein TypeProtease
Functionencodes a lysosomal cysteine protease that has emerged as a critical player in both immune function and neurodegenerative disease pathogenesis.
Primary ExpressionMicroglia, Macrophages, Dendritic cells
Molecular Weight37 kDa
Amino Acids331 aa
UniProt IDP07237
NCBI Gene ID1520
Ensembl IDENSG00000163131
OMIM600565
GeneCardsCTSS
Human Protein AtlasCTSS
Associated DiseasesAging
InteractionsAHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, APP/PS1
KG Connections60 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
CST3 Gene - Cystatin C
gene · KG edge: activates
CTSB Gene
gene · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: activates

Knowledge Graph (12 edges)

CTSS inhibits AHR
CTSS inhibits CTSD
CTSS inhibits LAMP2
CTSB activates CTSS
CTSL activates CTSS
CTSS activates JAK2
CTSS activates STAT3
CTSS inhibits APP
CTSS activates CX3CL1
CTSS activates CX3CR1

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