concept

CIRRHOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRRHOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

447Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CIRRHOSIS
Key Genes/Proteins	CCL2
Related Diseases	CANCER, HCV, HEPATOCELLULAR CARCINOMA, HYPERTENSION, NAFLD

Pathway Diagram

graph TD
    CIRRHOSIS["CIRRHOSIS"]
    CIRRHOSIS -->|"causes"| fibrosis["fibrosis"]
    CIRRHOSIS -->|"activates"| Pi3K["Pi3K"]
    CIRRHOSIS -->|"activates"| Akt["Akt"]
    CIRRHOSIS -->|"activates"| Mtor["Mtor"]
    CIRRHOSIS -->|"target for"| Autophagy["Autophagy"]
    CIRRHOSIS -->|"target for"| Mapk["Mapk"]
    CIRRHOSIS -->|"inhibits"| Mitophagy["Mitophagy"]
    CIRRHOSIS -->|"target for"| Immune_Response["Immune Response"]
    CIRRHOSIS -->|"activates"| Er_Stress["Er Stress"]
    gut_microbiome_modulation["gut microbiome modulation"] -->|"treats"| CIRRHOSIS
    OCLN["OCLN"] -->|"expressed in"| CIRRHOSIS
    EGF["EGF"] -->|"activates"| CIRRHOSIS
    CYP3A4["CYP3A4"] -->|"activates"| CIRRHOSIS
    PDK1["PDK1"] -->|"activates"| CIRRHOSIS
    MTOR["MTOR"] -->|"activates"| CIRRHOSIS
    EGFR["EGFR"] -->|"activates"| CIRRHOSIS
    ERCC3["ERCC3"] -->|"activates"| CIRRHOSIS
    CEBPB["CEBPB"] -->|"activates"| CIRRHOSIS
    CYP1A2["CYP1A2"] -->|"activates"| CIRRHOSIS

Outgoing (189)

Target	Relation	Type	Str
Fibrosis	associated_with	disease	1.00
Hepatitis	associated_with	disease	1.00
Fibrosis	causes	disease	0.95
MMP-9	activates	protein	0.90
Carcinoma	associated_with	disease	0.85
Als	biomarker_for	disease	0.85
Fibrosis	biomarker_for	disease	0.85
Fibrosis	therapeutic_target	disease	0.85
Oxidative Stress	therapeutic_target	pathway	0.80
Hepatitis	biomarker_for	disease	0.75
Diabetes	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Fibrosis	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Als	associated_with	disease	0.75
Inflammation	causes	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
Hypertension	causes	disease	0.75
Inflammation	therapeutic_target	disease	0.75
hepatic encephalopathy	associated_with	disease	0.70
Mtor	therapeutic_target	pathway	0.70
fibrosis	causes	process	0.70
Autophagy	therapeutic_target	pathway	0.70
Lipid Metabolism	therapeutic_target	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70
Oxidative Stress	activates	pathway	0.70
Fibrosis	treats	disease	0.65
Hepatitis	causes	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Hepatitis	treats	disease	0.65
Autoimmune	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Als	causes	disease	0.65
Carcinoma	causes	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	causes	disease	0.65
HEPATOCELLULAR CARCINOMA	increases_risk	disease	0.65
Als	treats	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Infection	biomarker_for	disease	0.65
Nafld	treats	disease	0.65
Infection	associated_with	disease	0.65
Fibrosis	regulates	disease	0.65
Mitophagy	contributes_to	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Autophagy	implicated_in	pathway	0.60

Incoming (258)

Source	Relation	Type	Str
Non-Alcoholic Fatty Liver Disease	causes	disease	0.90
INFLAMMATION	activates	gene	0.85
INFLAMMATION	therapeutic_target	gene	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
INFLAMMATION	causes	gene	0.85
INFLAMMATION	associated_with	gene	0.85
CANCER	associated_with	gene	0.85
MTOR	therapeutic_target	gene	0.75
AUTOPHAGY	therapeutic_target	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
MTORC1	therapeutic_target	gene	0.75
AMPK	therapeutic_target	gene	0.75
GENES	treats	gene	0.75
TNF-Α	regulates	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
TNF	regulates	gene	0.75
CYTOKINES	causes	gene	0.75
INFLAMMATION	regulates	gene	0.75
DIABETES MELLITUS	associated_with	gene	0.75
gut dysbiosis	associated_with	process	0.70
gut microbiome modulation	treats	process	0.70
LAMTOR1	therapeutic_target	gene	0.65
FGF21	therapeutic_target	gene	0.65
FGF19	therapeutic_target	gene	0.65
MICRORNAS	therapeutic_target	gene	0.65
MIRNAS	therapeutic_target	gene	0.65
CXCL10	therapeutic_target	gene	0.65
MTOR	expressed_in	gene	0.65
P62	expressed_in	gene	0.65
ULK1	expressed_in	gene	0.65
CANCER	expressed_in	gene	0.65
CANCER	therapeutic_target	gene	0.65
BCL-2	therapeutic_target	gene	0.65
INFLAMMATION	inhibits	gene	0.65
MITOPHAGY	inhibits	gene	0.65
CYTOKINES	inhibits	gene	0.65
PROINFLAMMATORY CYTOKINES	inhibits	gene	0.65
CD81	therapeutic_target	gene	0.65
CLDN1	therapeutic_target	gene	0.65
LDLR	therapeutic_target	gene	0.65
EGFR	therapeutic_target	gene	0.65
OCLN	therapeutic_target	gene	0.65
POLE	therapeutic_target	gene	0.65
MITOPHAGY	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
CYP2E1	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.65
MITOCHONDRIA	activates	gene	0.65
MITOCHONDRIA	inhibits	gene	0.65
ERK	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What causes IBA1 low/negative microglia in liver disease and how does this affec

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.710

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract describes IBA1 low/negative microglia in individuals with liver dis

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CIRRHOSIS in their description or question text

No additional research found