gene

atp5b

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atp5b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

5Outgoing

8Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ATP5B
Chromosome	12p13.33
Protein Type	Gene
Function	is a central hallmark of neurodegenerative diseases, and ATP5B plays a critical role in this pathology.
Molecular Weight	56 kDa
Amino Acids	529 aa
Exons	13
GeneCards	ATP5B
Human Protein Atlas	ATP5B
N-terminal region	Mitochondrial targeting sequence (cleaved after import)
P-loop NTP-binding domain	Walker A motif (GXXXXGKT) for nucleotide binding
Central domain	Forms the interface between subunits during conformational changes
C-terminal domain	Contains the Walker B motif (hhhhDE) for ATP hydrolysis
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

atp5b

gene · 2688 words

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Pathway Diagram

flowchart TD
    N0["ATP5B"]
    N1["Cirrhosis"]
    N0 -.->|"inhibits"| N1
    N2["Hepatitis"]
    N0 -->|"activates"| N2
    N3["CHOP"]
    N3 -.->|"inhibits"| N0
    N4["INSULIN RESISTANCE"]
    N4 -.->|"inhibits"| N0
    N5["AND"]
    N5 -.->|"inhibits"| N0
    N6["MITOCHONDRIA"]
    N6 -->|"activates"| N0
    N7["ROS"]
    N7 -->|"activates"| N0
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP5B	data_in	dataset_row	0.00
Cirrhosis	inhibits	disease	0.65
Hepatitis	activates	disease	0.65
SIRT1	activates	gene	0.60
TFAM	activates	gene	0.60

Incoming (8)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP5B	data_in	dataset_row	0.00
CHOP	inhibits	gene	0.60
AMPK	activates	gene	0.60
ATP	activates	gene	0.60
resveratrol	targets	drug	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ROS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning atp5b in their description or question text

No additional research found