protein

AMPA RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMPA RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

31Outgoing

43Incoming

0Experiments

0Debates

Summary

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are ionotropic glutamate receptors that mediate the majority of fast excitatory synaptic transmission in the brain. Dysfunction contributes to Alzheimer's disease, Parkinson's disease, and ALS.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	AMPA RECEPTOR
Primary Expression	hippocampus, prefrontal cortex, cortex, cerebral cortex
Pathways	glutamate signaling, unfolded protein response, BDNF-TrkB signaling, synaptic plasticity, Mtor
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	ALZHEIMER, BIN1, EPILEPSY, HDAC3, NMDA, NMDA RECEPTOR
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["AMPA RECEPTOR"]
    N1["ARHGEF7"]
    N0 -->|"modulates"| N1
    N2["NMDA RECEPTOR"]
    N0 -->|"activates"| N2
    N3["GLUTAMATE"]
    N0 -->|"activates"| N3
    N4["Genes"]
    N0 -->|"activates"| N4
    N5["Glutamate Signaling"]
    N0 -->|"activates"| N5
    N6["ALZHEIMER"]
    N0 -->|"inhibits"| N6
    N7["Alzheimer'S Disease"]
    N0 -->|"inhibits"| N7
    N8["EPIGENETIC"]
    N0 -->|"inhibits"| N8
    N9["Synaptic Plasticity"]
    N0 -->|"inhibits"| N9
    N10["disease"]
    N0 -->|"inhibits"| N10
    N11["ALZHEIMER'S"]
    N0 -->|"inhibits"| N11
    N12["Long-Term Potentiation"]
    N0 -->|"activates"| N12
    N0 -->|"interacts with"| N9
    N13["APP/PS1"]
    N0 -->|"interacts with"| N13

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein
    class N2 protein
    class N5 pathway
    class N6 gene
    class N7 disease
    class N9 pathway
    class N10 disease
    class N12 pathway

Outgoing (31)

Target	Relation	Type	Str
hippocampus	expressed_in	brain_region	0.80
neurons	expressed_in	cell_type	0.80
glutamate signaling	activates	pathway	0.70
prefrontal cortex	expressed_in	brain_region	0.70
neural stem cells	expressed_in	cell_type	0.70
unfolded protein response	activates	pathway	0.70
Als	regulates	disease	0.60
cerebral cortex	expressed_in	brain_region	0.60
Alzheimer	regulates	disease	0.60
cortex	expressed_in	brain_region	0.60
synaptic plasticity	activates	pathway	0.60
BDNF-TrkB signaling	activates	pathway	0.60
Als	activates	disease	0.60
Epilepsy	activates	disease	0.60
Als	inhibits	disease	0.60
Epilepsy	inhibits	disease	0.60
Purkinje cells	expressed_in	cell_type	0.60
Mtor	inhibits	pathway	0.55
Synaptic Transmission	interacts_with	pathway	0.50
GLUTAMATE	activates	concept	0.50
Glutamate Signaling	activates	pathway	0.50
ALZHEIMER	inhibits	gene	0.50
Alzheimer'S Disease	inhibits	disease	0.50
Synaptic Plasticity	inhibits	pathway	0.50
NMDA RECEPTOR	activates	protein	0.50
ALZHEIMER'S	inhibits	concept	0.50
Long-Term Potentiation	activates	pathway	0.50
Synaptic Plasticity	interacts_with	pathway	0.50
APP/PS1	interacts_with	concept	0.50
EAAT4	associated_with	protein	0.50
disease	inhibits	disease	0.50

Incoming (43)

Source	Relation	Type	Str
epilepsy	involves	disease	0.70
NLGN1	interacts_with	gene	0.60
TNF	implicated_in	gene	0.60
BDNF	activates	gene	0.60
BDNF	inhibits	gene	0.60
NLGN1	activates	gene	0.60
APP/PS1	associated_with	gene	0.60
TNF	causes	gene	0.60
anxiety	involves	disease	0.60
BIN1	regulates	gene	0.60
RAB11	regulates	gene	0.60
HDAC3	activates	gene	0.60
APP	interacts_with	gene	0.60
HDAC3	interacts_with	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC3	regulates	gene	0.60
BDNF	associated_with	gene	0.60
APP	associated_with	gene	0.60
TRKB	associated_with	gene	0.60
PPAR	activates	gene	0.60
PPAR	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
GABA	activates	gene	0.60
EPILEPSY	inhibits	gene	0.60
MTORC1	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ARF6	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GABA	activates	gene	0.60
GABA	expressed_in	gene	0.60
Alzheimer's disease	involves	disease	0.60
MTOR	inhibits	gene	0.60
PVALB	associated_with	gene	0.60
SST	associated_with	gene	0.60
RAC1	regulates	gene	0.60
ARHGEF7	regulates	gene	0.60
depression	involves	disease	0.60
EPILEPSY	activates	gene	0.50
BIN1	interacts_with	gene	0.50
HDAC3	activates	gene	0.50
HDAC3	interacts_with	gene	0.50
HDAC3	inhibits	gene	0.50
NMDA	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMPA RECEPTOR in their description or question text

No additional research found