concept

ST3GAL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ST3GAL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

174Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	ST3GAL2
Key Genes/Proteins	ABCA1, App, ASTROCYTE, AUTOPHAGY, B3GALT4, B4GALNT1
Related Diseases	Als, ALS, Alzheimer's disease
Related Pathways	autophagy, Autophagy, autophagy pathway

Pathway Diagram

graph TD
    ST3GAL2["ST3GAL2"]
    style ST3GAL2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ST3GAL2 -->|"regulates"| GD1a_Biosynthesis["GD1a Biosynthesis"]
    ST3GAL2 -->|"upregulates"| GT1b["GT1b"]
    ST3GAL2 -->|"mediates"| _2_3_Sialylated_Glycosphingoli["alpha2-3 Sialylated Glycosphingolipids"]
    ST3GAL2 -->|"co_expressed_with"| ST3GAL3([ST3GAL3])
    ST3GAL2 -->|"involved_in"| Ganglioside_Synthesis["Ganglioside Synthesis"]
    ST3GAL2 -->|"interacts"| ST8SIA1([ST8SIA1])
    ST3GAL2 -.->|"inhibits"| Parkinson["Parkinson"]
    ST3GAL2 -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ST3GAL2 -->|"studied_in"| neurodegeneration["neurodegeneration"]
    Nerve_Injury["Nerve Injury"] -->|"upregulates"| ST3GAL2
    h_12599989["h-12599989"] -->|"targets"| ST3GAL2
    ST8SIA1 -->|"interacts"| ST3GAL2
    PARKINSON_S_DISEASE([PARKINSON'S DISEASE]) -.->|"inhibits"| ST3GAL2
    PARKINSON([PARKINSON]) -.->|"inhibits"| ST3GAL2
    NEURODEGENERATION([NEURODEGENERATION]) -.->|"inhibits"| ST3GAL2

Outgoing (115)

Target	Relation	Type	Str
GD1a Biosynthesis	regulates	process	0.95
ST3GAL3	co_expressed_with	gene	0.90
Ganglioside Synthesis	involved_in	pathway	0.85
ALS	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
neurodegeneration	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
ST8SIA1	interacts_with	gene	0.65
ALS	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Parkinson	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Epilepsy	inhibits	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	expressed_in	disease	0.65
EPILEPSY	inhibits	gene	0.60
ST3GAL3	associated_with	gene	0.60
Neuron	inhibits	cell_type	0.60
DNA	expressed_in	gene	0.60
Dna Methylation	expressed_in	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
MICROGLIA	activates	gene	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
AUTOPHAGY	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ST8SIA1	regulates	gene	0.60
PARKINSON	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
B3GALT4	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.60
ST3GAL3	expressed_in	gene	0.60
Astrocyte	regulates	cell_type	0.60
App	inhibits	protein	0.60
PARKINSON	expression	disease	0.60
CANCER	modifies	disease	0.60
ST6GAL1	methylates	gene	0.60
ST8SIA1	activates	gene	0.60
Autophagy	regulates	pathway	0.60
App	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
Ras	associated_with	protein	0.60
Ras	activates	protein	0.60
neurons	regulates	cell_type	0.60
neurons	expressed_in	cell_type	0.60
lipid metabolism	participates_in	pathway	0.60

Incoming (59)

Source	Relation	Type	Str
h-12599989	targets	hypothesis	0.90
GBM	associated_with	gene	0.70
ST8SIA1	interacts_with	gene	0.65
B3GALT4	inhibits	gene	0.60
PARKINSON	expressed_in	gene	0.60
ST3GAL3	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
B3GALT4	regulates	gene	0.60
B3GALT4	expressed_in	gene	0.60
RUNX1	activates	gene	0.60
MYELIN	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
GAL	expressed_in	gene	0.60
GATA1	activates	gene	0.60
GATA2	activates	gene	0.60
TLR2	therapeutic_target	gene	0.60
ST6GAL1	expressed_in	gene	0.60
phagocytosis	activates	process	0.55
B4GALNT1	interacts_with	gene	0.55
C1Q	activates	gene	0.55
PARKINSON'S	inhibits	concept	0.50
Parkinson's Disease	inhibits	disease	0.50
disease	inhibits	disease	0.50
Substantia Nigra	inhibits	entity	0.50
BECLIN-1	activates	protein	0.50
Autophagy	activates	process	0.50
VPS34	activates	protein	0.50
NEURONS	activates	concept	0.50
Pain	associated_with	disease	0.50
Autophagy	regulates	process	0.50
Substantia Nigra	expressed_in	entity	0.50
NEURONS	regulates	concept	0.50
NEURONS	inhibits	concept	0.50
Proteins	associated_with	protein	0.50
Proteins	inhibits	protein	0.50
GALNT3	expressed_in	gene	0.50
TUMOR	expressed_in	disease	0.50
cancer	expressed_in	disease	0.50
TLR2	associated_with	gene	0.50
NEURONS	expressed_in	concept	0.50
SGMS1/SGMS2	debate_co_mention	gene	0.45
SMPD1	debate_co_mention	gene	0.45
SREBF2	debate_co_mention	gene	0.45
RANK	debate_co_mention	gene	0.45
SGMS1	debate_co_mention	gene	0.45
neuroinflammation	debate_co_mention	process	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.985

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

Related Research

Hypotheses and analyses mentioning ST3GAL2 in their description or question text

No additional research found