Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SGMS1/SGMS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | SGMS1/SGMS2 |
| Key Genes/Proteins | ABCA1/LDLR/SREBF2, BACE1, CYP46A1, FLOT1, LDLR, RANK |
| Related Diseases | neurodegeneration |
| Related Pathways | sphingolipid___ceramide_signaling |
graph TD
SGMS1_SGMS2[SGMS1/SGMS2]
SGMS1_SGMS2 -->|debate_co_mention| SMPD1[SMPD1]
SGMS1_SGMS2 -->|debate_co_mention| SREBF2[SREBF2]
SGMS1_SGMS2 -->|debate_co_mention| ST3GAL2[ST3GAL2]
SGMS1_SGMS2 -->|debate_co_mention| ST8SIA1[ST8SIA1]
SGMS1_SGMS2 -->|debate_co_mention| ST3GAL2_ST8SIA1[ST3GAL2/ST8SIA1]
SGMS1_SGMS2 -->|implicated in| neurodegeneration[neurodegeneration]
SGMS1_SGMS2 -->|involved_in| sphingolipid___ceramide_signal[sphingolipid___ceramide_signaling]
SGMS1_SGMS2 -->|data_in| benchmark_ot_ad_answer_key_SGM[benchmark_ot_ad_answer_key:SGMS1/SGMS2]
h_fdb07848[h-fdb07848] -->|targets| SGMS1_SGMS2
CYP46A1[CYP46A1] -->|debate_co_mention| SGMS1_SGMS2
FLOT1[FLOT1] -->|debate_co_mention| SGMS1_SGMS2
LDLR[LDLR] -->|debate_co_mention| SGMS1_SGMS2
neuroinflammation[neuroinflammation] -->|debate_co_mention| SGMS1_SGMS2
RANK[RANK] -->|debate_co_mention| SGMS1_SGMS2
SGMS1[SGMS1] -->|debate_co_mention| SGMS1_SGMS2
ABCA1_LDLR_SREBF2[ABCA1/LDLR/SREBF2] -->|co_associated_with| SGMS1_SGMS2
BACE1[BACE1] -->|co_associated_with| SGMS1_SGMS2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SGMS1/SGMS2 | data_in | dataset_row | 0.00 |
| ST3GAL2/ST8SIA1 | debate_co_mention | gene | 0.45 |
| SMPD1 | debate_co_mention | gene | 0.45 |
| SREBF2 | debate_co_mention | gene | 0.45 |
| ST3GAL2 | debate_co_mention | gene | 0.45 |
| ST8SIA1 | debate_co_mention | gene | 0.45 |
| ST3GAL2/ST8SIA1 | co_associated_with | gene | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| sphingolipid___ceramide_signaling | involved_in | pathway | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SGMS1/SGMS2 | data_in | dataset_row | 0.00 |
| h-fdb07848 | targets | hypothesis | 0.50 |
| CYP46A1 | debate_co_mention | gene | 0.45 |
| FLOT1 | debate_co_mention | gene | 0.45 |
| LDLR | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| SGMS1 | debate_co_mention | gene | 0.45 |
| ABCA1/LDLR/SREBF2 | co_associated_with | gene | 0.40 |
| BACE1 | co_associated_with | gene | 0.40 |
| CYP46A1 | co_associated_with | gene | 0.40 |
| FLOT1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sphingomyelin Synthase Activators for Raft Remodeling | 0.692 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Validation: Membrane-Nucleation in iPSC Neurons | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Ceramide metabolism in oxidative and glycolytic muscle: Significance for lipid-i [PMID:41707846] | Eurén T, Flockhart M, Strmeň T, Zhou X, | Molecular metabolism | 2026 | 0 |
| Effect of Lactiplantibacillus mudanjiangensis strain isolated from post-fermente [PMID:41270786] | Horie M, Tabata Y, Aiso C, Gotoh Y | Beneficial microbes | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Identification of Anticancer Target Combinations to Treat Pancreatic Cancer and [PMID:40807373] | ["Wang F", "Wu C", "Huang K"] | Molecules (Basel, Switzerland) | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardi [PMID:37298446] | Gruzdeva O, Dyleva Y, Belik E, Uchasova | International journal of molec | 2023 | 0 |
| Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response t [PMID:31517509] | Gupta G, Baumlin N, Poon J, Ahmed B, Chi | American journal of respirator | 2020 | 0 |
| Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disru [PMID:30770781] | Zheng K, Chen Z, Feng H, Chen Y, Zhang C | Cell death & disease | 2019 | 0 |
| Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid R [PMID:31114500] | Bilal F, Montfort A, Gilhodes J, Garcia | Frontiers in pharmacology | 2019 | 0 |
| Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2. [PMID:30779713] | Pekkinen M, Terhal PA, Botto LD, Henning | JCI insight | 2019 | 0 |
| Health status of long-term sick leave and working female teachers in Germany: A [PMID:29063910] | ["Br\u00fctting J", "Druschke D", "Spitz | International journal of occup | 2018 | 0 |
| Tuning CRISPR-Cas9 Gene Drives in [PMID:29348295] | ["Roggenkamp E", "Giersch R", "Schrock M | G3 (Bethesda, Md.) | 2018 | 0 |
| White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneou [PMID:28916600] | ["Shah B", "Baber U", "Pocock S", "Kruco | Circulation. Cardiovascular in | 2017 | 0 |
| Combination antiretroviral therapy (cART) restores HIV-1 infection-mediated impa [PMID:28186978] | ["Liu M", "Zhao M", "Kong W", "Tang L", | Oncotarget | 2017 | 0 |
| Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologic [PMID:27531958] | ["F\u00f6ldy C", "Darmanis S", "Aoto J", | Proceedings of the National Ac | 2016 | 0 |
| Delayed coupling to feedback inhibition during a critical period for the integra [PMID:25533485] | ["Temprana S", "Mongiat L", "Yang S", "T | Neuron | 2015 | 0 |
| Ascidians as excellent models for studying cellular events in the chordate body [PMID:23995746] | ["Ogura Y", "Sasakura Y"] | The Biological bulletin | 2013 | 0 |
| Nutrient-induced insulin resistance in human skeletal muscle. [PMID:15078172] | ["Krebs M", "Roden M"] | Current medicinal chemistry | 2004 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning SGMS1/SGMS2 in their description or question text
No additional research found