IL-6

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Interleukin-6 (IL-6) is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory functions, central to neuroinflammation in neurodegeneration. In the brain, IL-6 is produced by microglia, astrocytes, and neurons, signaling through classical (membrane-bound IL-6R) and trans-signaling (soluble IL-6R + gp130) pathways. Elevated IL-6 in CSF and plasma is associated with AD, PD, and cognitive decline. Chronic IL-6 trans-signaling drives neuroinflammation, blood-brain barrier disruption, and impaired neurogenesis. However, acute IL-6 classical signaling supports neuroprotection and neuronal survival. Therapeutic strategies focus on selective trans-signaling inhibition (sgp130Fc) to block pathological inflammation while preserving protective signaling.

View on Wiki →

graph TD
    IL_6["IL-6"]
    IL_6 -->|"phosphorylates"| BECN1["BECN1"]
    IL_6 -->|"activates"| A1_reactive_astrocyte["A1 reactive astrocyte"]
    IL_6 -->|"activates"| STAT3["STAT3"]
    IL_6 -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
    IL_6 -->|"interacts"| MMP9["MMP9"]
    IL_6 -->|"activates"| neurodegeneration["neurodegeneration"]
    IL_6 -->|"activates"| BACE1["BACE1"]
    IL_6 -->|"activates"| NF_B["NFkappaB"]
    STAT3 -->|"regulates"| IL_6
    BMSC_exos["BMSC-exos"] -->|"regulates"| IL_6
    Hippo["Hippo"] -->|"regulates"| IL_6
    cGas_STING_pathway["cGas/STING pathway"] -->|"regulates"| IL_6
    donepezil["donepezil"] -->|"inhibits"| IL_6
    IL6["IL6"] -->|"target for"| IL_6
    MMP9 -->|"target for"| IL_6

No additional research found