gene 630 words KG: HSPA9
Contents

HSPA9 Gene

🧬 Gene Info
Gene SymbolHSPA9
Chromosome5q31.2.
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmost cell lines
Molecular Weight73.6 kDa
Amino Acids679 aa
PathwaysApoptosis, Oxidative Phosphorylation
Ensembl IDENSG00000113014
GeneCardsHSPA9
Human Protein AtlasHSPA9
BrainHigh expression in neurons, especially dopaminergic neurons
HeartHigh expression in cardiac muscle
LiverHigh expression in hepatocytes
Associated DiseasesParkinson
Interactionsaco2, ACO2, AKT, AND, ATP, BECN1
KG Connections180 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
ACO2 — Aconitase 2
gene · KG edge: expressed_in
BECN1 Gene
gene · KG edge: inhibits
BNIP3 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

VDAC1 expressed_in HSPA9
HSPA9 expressed_in CYCS
HSPA9 expressed_in ACO2
HSPA9 therapeutic_target GLUD1
HSPA9 expressed_in SNCA
HSPA9 therapeutic_target LRPPRC
HSPA9 therapeutic_target NDUFS2
HSPA9 therapeutic_target NDUFS1
HSPA9 expressed_in SDHA
BNIP3 inhibits HSPA9

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