gene 1,032 words KG: ARSA
Contents

ARSA Gene

🧬 Gene Info
Gene SymbolARSA
Full NameArylsulfatase A
Chromosome22q13.33
Protein TypeEnzyme
FunctionARSA is a lysosomal hydrolase (517 amino acids, 54 kDa) that catalyzes desulfation of cerebroside 3-sulfate (sulfatide) within myelin sheaths.
Primary Expressionwhite matter regions rich in myelin
Molecular Weight54 kDa
Amino Acids517 aa
Exons8
UniProt IDP15289
NCBI Gene ID25
Ensembl IDENSG00000166295
OMIM607574
GeneCardsARSA
Human Protein AtlasARSA
Associated Diseasesneurodegeneration
InteractionsAGING, AUTOPHAGY, CCL2, CCL3, CTSD, CXCL12
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Myelin Basic Protein (MBP) - Biomarker
biomarker · KG edge: contributes_to
Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: activates
CXCL12 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ARSA associated_with GLA
ARSA associated_with GALC
ARSA contributes_to PSAP
CCL3 activates ARSA
RAB27A activates ARSA
SERPINE1 activates ARSA
LAMP1 activates ARSA
ARSA activates LAMP2
ARSA activates CXCL12
ARSA activates CTSD

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