gene 931 words KG: NOS2
Contents

NOS2 - Nitric Oxide Synthase 2

🧬 Gene Info
Gene SymbolNOS2
Full NameNitric Oxide Synthase 2
AliasesInducible Nitric Oxide Synthase
Chromosome17q11.2
Protein FamilyNitric oxide synthase family
Protein TypeEnzyme
FunctionIn the immune system, iNOS-mediated NO production serves several critical functions
Primary Expressionastrocytes, microglia, and neurons in response to injury or disease
Molecular Weight131 kDa
Exons26
PathwaysNF-κB
GeneCardsNOS2
Human Protein AtlasNOS2
Associated DiseasesAls, Alzheimer, Cancer, Carcinoma
InteractionsABCB1, ABCG2, AND, APOPTOSIS, ARG1, ATG7
KG Connections235 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
ARG1 — Arginase 1
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PANX1 regulates NOS2
S100B regulates NOS2
RELB regulates NOS2
P2RY1 regulates NOS2
CASP3 regulates NOS2
SOCS3 regulates NOS2
TRPA1 regulates NOS2
CXCL2 regulates NOS2
SNAP25 regulates NOS2
P2RX7 regulates NOS2

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