| Gene Symbol | ARAF |
| Full Name | A-Raf Proto-Oncogene, Serine/Threonine Kinase |
| Protein Family | RAF family, MAP3K |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase belonging to the RAF family (along with BRAF and RAF1/C-Raf). |
| Primary Expression | Ubiquitous, highest in brain, heart, lung |
| Molecular Weight | 67 kDa |
| Amino Acids | 606 aa |
| Pathways | MAPK, MAPK pathway |
| UniProt ID | [P04003](https://www.uniprot.org/uniprot/P04003) |
| Ensembl ID | ENSG00000078061 |
| GeneCards | ARAF |
| Human Protein Atlas | ARAF |
| CR1 (Conserved Region 1) | Contains the RAS-binding domain (RBD) and a cysteine-rich domain (CRD) that mediates membrane localization and interactions with RAS-GTP [@map2021] |
| CR2 | A regulatory region containing a serine-rich domain with phosphorylation sites that control kinase activity |
| Associated Diseases | neurodegeneration |
| Interactions | ATG12, ATG16L1, ATG3, ATG7, ATG9A, AUTOPHAGY |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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