protein 1,094 words KG: ARAF
Contents

A-Raf Protein

🔬 Protein Info
Gene SymbolARAF
Protein FamilyRAF family, MAP3K
Protein TypeKinase
Functionis a serine/threonine protein kinase belonging to the RAF family (along with BRAF and RAF1/C-Raf).
Primary ExpressionUbiquitous, highest in brain, heart, lung
Molecular Weight67 kDa
Amino Acids606 aa
PathwaysMAPK, MAPK pathway
UniProt ID[P04003](https://www.uniprot.org/uniprot/P04003)
Ensembl IDENSG00000078061
GeneCardsARAF
Human Protein AtlasARAF
Associated Diseasesneurodegeneration
InteractionsATG12, ATG16L1, ATG3, ATG7, ATG9A, AUTOPHAGY
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (5)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
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Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (15)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: activates
ATG3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ATG9A activates ARAF
ARAF activates BECLIN1
ARAF activates ATG12
ARAF activates MYC
ARAF activates CDK12
ARAF activates ATG3
ARAF activates ATG7
ARAF activates CDK4
ARAF activates ATG16L1
ARAF activates LC3

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