gene

NTN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

196Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

2Debates

Summary

NTN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, interacts with. Associated with AD, ADH, ALI. Connected to 90 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTN1
Aliases	Page for NTN1 Gene
Protein Type	Ligand
Target Class	Ligand
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Modulation of axon guidance and neuronal survival pathways
Druggability	Low (0.36)
Clinical Stage	Phase I
Pathways	MAPK, PI3K
UniProt ID	O95631
Ensembl ID	ENSG00000165899
GeneCards	NTN1
Human Protein Atlas	NTN1
DCC (Deleted in Colorectal Cancer)	dependence receptor mediating attractive responses
UNC5H1-4 (UNC5A-D)	dependence receptors mediating repulsive responses
Associated Diseases	AD, ADH, ALI, Als, Alzheimer
Known Drugs/Compounds	Netrin-1 Inhibitor, Pharmacological targeting, rapamycin
Interactions	AKT, AMYLOID, AND, DNA, GPNMB, JUN
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Netrin-1 Gradient Restoration
KG Connections	196 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NTN1 — AlphaFold O95631 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTN1["NTN1"] -->|"activates"| Ms["Ms"]
    NTN1["NTN1"] -->|"expressed in"| Als["Als"]
    NTN1["NTN1"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    NTN1["NTN1"] -->|"biomarker for"| Ms_1["Ms"]
    NTN1["NTN1"] -->|"expressed in"| Alzheimer_2["Alzheimer"]
    NTN1["NTN1"] -->|"associated"| Alzheimer_3["Alzheimer"]
    h_05b8894a["h-05b8894a"] -->|"therapeutic target"| NTN1["NTN1"]
    h_05b8894a_4["h-05b8894a"] -->|"targets"| NTN1["NTN1"]
    JUN["JUN"] -->|"activates"| NTN1["NTN1"]
    VGF["VGF"] -->|"associated"| NTN1["NTN1"]
    style NTN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (136)

Target	Relation	Type	Str
Peripheral Nerve Regeneration	promotes	process	0.95
EMT	promotes	process	0.95
Peripheral Nerve Repair	associated_with	process	0.95
Epithelial-Mesenchymal Transition	inhibits	process	0.95
vascular niche formation	promotes	process	0.95
Endometrial Cancer	therapeutic_target	disease	0.95
Tumor Growth	promotes	phenotype	0.90
Endothelial Cells	expressed_in	cell_type	0.90
Epithelial-Mesenchymal Transition	promotes	process	0.90
Cancer	involved_in	disease	0.90
endometrial cancer	drives	disease	0.90
tumour growth	promotes	phenotype	0.90
PI3K-AKT	activates	entity	0.90
EMT	inhibits	entity	0.90
Peripheral Nerve Injury	upregulates	disease	0.90
MTOR	activates	entity	0.90
PERIPHERAL NERVE REPAIR	associated_with	entity	0.90
Cancer	targets	disease	0.90
Exosome	component_of	organelle	0.90
Angiogenesis	associated_with	process	0.90
Axon Regeneration	associated_with	process	0.90
peripheral nerve injury recovery	promotes	phenotype	0.88
Epithelial-mesenchymal transition	drives	process	0.88
ANGIOGENESIS	associated_with	entity	0.85
Cancer	contributes_to	disease	0.85
Cancer metastasis	promotes	process	0.85
AXON GUIDANCE	activates	entity	0.85
Cancer Metastasis	involved_in	process	0.85
Therapeutic Target	associated_with	mechanism	0.85
Endometrial Cancer	contributes_to	disease	0.85
FOCAL ADHESION	activates	entity	0.85
Cancer Metastasis	inhibits	process	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Growth Cone Guidance	mediates	process	0.82
Cancer Progression	promotes	process	0.80
ALZHEIMER'S DISEASE	associated_with	entity	0.80
Alzheimer	expressed_in	disease	0.65
Ms	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Akt	activates	pathway	0.60
TAU	interacts_with	gene	0.60
Rb	biomarker_for	protein	0.60
Amyloid	interacts_with	pathway	0.60
Complement	associated_with	pathway	0.60
Endocytosis	associated_with	pathway	0.60

Incoming (60)

Source	Relation	Type	Str
Netrin-1 Inhibitor	targets	drug	0.95
Pharmacological targeting	targets	drug	0.95
h-05b8894a	targets	hypothesis	0.90
ENDOTHELIAL CELL	expressed_in	entity	0.90
Endothelial Cells	expressed_in	cell_type	0.85
Endothelial Cell	expressed_in	cell_type	0.85
LET7A-5P	downregulates	entity	0.75
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
PTN	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
AKT	expressed_in	gene	0.60
GPNMB	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
AXON REGENERATION	associated_with	gene	0.60
AXON	associated_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
TAU	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
rapamycin	targets	drug	0.60
JUN	activates	gene	0.60
VGF	associated_with	gene	0.60
TARDBP	interacts_with	gene	0.60
EXOSOMES	expressed_in	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
LET7A-5P	activates	gene	0.60
AKT	activates	gene	0.60
GPNMB	associated_with	gene	0.60
NPTX2	associated_with	gene	0.60
JUN	associated_with	gene	0.60
SNRNP70	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
PTN	associated_with	gene	0.60
apoptosis	activates	pathway	0.55
ALZHEIMER	co_discussed	gene	0.50
AMYLOID	co_discussed	gene	0.50
GPNMB	co_discussed	protein	0.50
NPTX2	co_discussed	protein	0.50
CERS6	debate_co_mention	gene	0.45
EPHB4	debate_co_mention	gene	0.45
HSPG2	debate_co_mention	gene	0.45
CERS2	debate_co_mention	gene	0.45
EPHB4	co_discussed	gene	0.40
C1QA	co_discussed	gene	0.40
SMPD1	co_discussed	gene	0.40
CERS2	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Netrin-1 Gradient Restoration	0.595	neurodegeneration	4R-tau strain-specific spreading pattern

Mentioning Analyses (1)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Phase I trial of NP137 in advanced endometrial cancer	clinical	advanced endometrial carcinoma	0.950	0.00	human patients	proposed	N/A
Anti-netrin-1 antibody efficacy in EC mouse model	validation	endometrial carcinoma	0.900	0.00	endometrial carcinoma mouse mo	proposed	N/A
NP137 antibody treatment effects on EMT and metastasis in mouse SCC	validation	Skin squamous cell carcinoma	0.900	0.00	Primary mouse model	proposed	N/A
Multi-omics analysis of NP137 mechanism in patient biopsies	exploratory	endometrial carcinoma	0.900	0.00	human patient biopsies	proposed	N/A
NP137 treatment of A549 human cancer cell xenografts	validation	Cancer	0.850	0.00	A549 human cancer cell xenogra	proposed	N/A
Combination therapy with NP137 and carboplatin-paclitaxel	validation	endometrial carcinoma	0.850	0.00	endometrial carcinoma mouse mo	proposed	N/A
Netrin-1 and UNC5B knockdown effects on EMT in vitro	exploratory	Cancer	0.850	0.00	EPCAM+ tumor cells in vitro	proposed	N/A
Netrin-1 expression in primary mouse skin SCC model with spontaneous E	validation	Skin squamous cell carcinoma	0.800	0.00	Primary mouse model	proposed	N/A
Netrin-1 expression analysis in human endometrial carcinomas	exploratory	endometrial carcinoma	0.800	0.00	human endometrial carcinoma ti	proposed	N/A
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Proteomic landscape of Alzheimer's disease: emerging technologies, advances and [PMID:40660303]	Yarbro JM, Shrestha HK, Wang Z, Zhang X,	Mol Neurodegener	2025	1
Netrin-1-engineered endothelial cell exosomes induce the formation of pre-regene [PMID:38941462]	Huang J, Li J, Li S, Yang X, Huo N, Chen	Sci Adv	2024	1
Pharmacological targeting of netrin-1 inhibits EMT in cancer. [PMID:37532929]	Lengrand J, Pastushenko I, Vanuytven S,	Nature	2023	1
Dissecting Detergent-Insoluble Proteome in Alzheimer's Disease by TMTc-Corrected [PMID:37356496]	Zaman M, Fu Y, Chen PC, Sun H, Yang S, W	Mol Cell Proteomics	2023	1
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. [PMID:37532934]	Cassier PA, Navaridas R, Bellina M, Rama	Nature	2023	1
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-r [PMID:39693351]	Furtado J, Geraldo LH, Leser FS, Bartkow	Proceedings of the National Ac	2024	0
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vasc [PMID:35082286]	Qian W, Hadi T, Silvestro M, Ma X, River	Nature communications	2022	0
Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and [PMID:32273485]	Aslanpour S, Han S, Schuurmans C, Kurras	The Journal of neuroscience :	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Appropriate referring. [PMID:31253886]	A J Wight	British dental journal	2019	0
Male contraception: where are we going and where have we been? [PMID:31537614]	["Reynolds-Wright J", "Anderson R"]	BMJ sexual & reproductive heal	2019	0
Histological findings in TMJ treated with high condilectomy for internal derange [PMID:29880328]	["Pucci R", "Vellone V", "Ramieri V", "C	Journal of cranio-maxillo-faci	2018	0
Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorti [PMID:28143892]	["Wei X", "Gao P", "Pu Y", "Li Q", "Yang	Clinical science (London, Engl	2017	0
Hemophilia A treatment: disruptive technology ahead. [PMID:27034415]	["Makris M"]	Blood	2016	0
Novel INHAT repressor (NIR) is required for early lymphocyte development. [PMID:25201955]	["Ma C", "Pusso A", "Wu L", "Zhao Y", "H	Proceedings of the National Ac	2014	0
daf-16 integrates developmental and environmental inputs to mediate aging in the [PMID:11747825]	["Henderson S", "Johnson T"]	Current biology : CB	2001	0

Debates (2)

Multi-agent debates referencing this entity

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 7 · Score: 0.91 · 2026-04-10

Related Research

Hypotheses and analyses mentioning NTN1 in their description or question text

No additional research found

NTN1

Understanding Entity Pages

Summary

Wiki Pages (3)

NTN1 Gene - Netrin 1

CNTN1 Protein

CNTN1 Gene

Pathway Diagram

Outgoing (136)

Incoming (60)

Targeting Hypotheses (1)

Mentioning Analyses (1)

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (10)

Related Papers (16)

Debates (2)

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

Related Research