| Gene Symbol | NTN1 |
| Aliases | Page for NTN1 Gene |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Modulation of axon guidance and neuronal survival pathways |
| Druggability | Low (0.36) |
| Clinical Stage | Phase I |
| Pathways | MAPK, PI3K |
| UniProt ID | O95631 |
| Ensembl ID | ENSG00000165899 |
| GeneCards | NTN1 |
| Human Protein Atlas | NTN1 |
| DCC (Deleted in Colorectal Cancer) | dependence receptor mediating attractive responses |
| UNC5H1-4 (UNC5A-D) | dependence receptors mediating repulsive responses |
| Associated Diseases | AD, ADH, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Netrin-1 Inhibitor, Pharmacological targeting, rapamycin |
| Interactions | AKT, AMYLOID, AND, DNA, GPNMB, JUN |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | Netrin-1 Gradient Restoration |
| KG Connections | 196 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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