Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| MTORC1 | activates | protein | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GATOR1 | inhibits | protein | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4-Specific Proteolytic Fragment Inhibition Therapy | 0.777 | Alzheimer's disease | - |
| Microglial Efferocytosis Enhancement via GPR32 Superagonists | 0.704 | neurodegeneration | Neuroinflammation resolution mechanisms |
| SASP-Secreted MMP-9 from Senescent Microglia Generates Patho | 0.682 | ALS | What are the mechanisms by which microgl |
| CSF Soluble TREM2 Fragment Ratio as Priming State Indicator | 0.680 | biomarkers | What biomarkers can reliably detect micr |
| S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF | 0.647 | - | Blood-brain barrier permeability changes |
| Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro | 0.613 | neurodegeneration | What are the mechanisms by which gut mic |
| RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre | 0.442 | neurodegeneration | How do perivascular cells specifically r |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| GWAS of plasma NfL in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| GWAS of plasma pTau217 in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| Dairy intake and dementia risk in Malmö Diet and Cancer cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Swedish community-based adults | proposed | N/A |
| GWAS of plasma pTau181 in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| GWAS of plasma GFAP in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| KEEPS Continuation: Long-term effects of menopausal hormone therapy on | clinical | Alzheimer's disease | 0.950 | 0.00 | recently menopausal women with | proposed | N/A |
| GWAS of composite biomarker score | exploratory | Alzheimer's disease | 0.900 | 0.00 | human patients - East Asian co | proposed | N/A |
| Reelin glycoprotein treatment rescue experiment | validation | Alzheimer's disease | 0.900 | 0.00 | mice | proposed | N/A |
| AGE-mediated HCC induction in animal models with β-catenin signaling | validation | Hepatocellular carcinoma | 0.900 | 0.00 | animal models (species not spe | proposed | N/A |
| APOE4 association with TDP-43 pathology in AD | exploratory | Alzheimer's disease | 0.750 | 0.00 | human patients | proposed | N/A |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305] | Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z | Mol Ther | 2026 | 1 |
| Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300] | Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W | Biomed Pharmacother | 2025 | 1 |
| The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814] | Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, | Sci Immunol | 2021 | 1 |
| Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075] | Yu Y, Ye RD | Cell Mol Neurobiol | 2015 | 1 |
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998] | ["Neprelyuk O", "Romanenko I", "Irza O", | Current protein & peptide scie | 2026 | 0 |
| Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545] | ["List M", "Beck-Sickinger A"] | Journal of the American Chemic | 2026 | 0 |
| Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947] | Lin YC, Igarashi M, Sakai Y, Nishikawa M | Biochem Biophys Res Commun | 2026 | 0 |
| Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436] | ["Dutta A", "Gurusubramanian G", "Roy V" | Histochemistry and cell biolog | 2026 | 0 |
| Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650] | ["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge | Advanced science (Weinheim, Ba | 2026 | 0 |
| Decoding microglial immunometabolism: a new frontier in Alzheimer's disease rese [PMID:40149001] | Jung ES, Choi H, Mook-Jung I | Molecular neurodegeneration | 2025 | 0 |
| Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis [PMID:38917486] | Zhang N, Chen P, Liang X, Sun J, Liu Q, | Aging | 2024 | 0 |
| Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848] | Liu E, Zhang Y, Wang JZ | Transl Neurodegener | 2024 | 0 |
| Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848] | Liu E, Zhang Y, Wang JZ | Translational neurodegeneratio | 2024 | 0 |
| Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic li [PMID:38297127] | Fan W, Adebowale K, Váncza L, Li Y, Rabb | Nature | 2024 | 0 |
| Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming a [PMID:36154605] | ["Koerich S", "Parreira G", "de Almeida | Current neuropharmacology | 2023 | 0 |
| Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR [PMID:37442582] | Strickson S, Houslay KF, Negri VA, Ohne | The European respiratory journ | 2023 | 0 |
| Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187] | ["Sanges S", "Rice L", "Tu L", "Valenzi | Annals of the rheumatic diseas | 2023 | 0 |
| The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Depos [PMID:36012305] | Chen Y, Liu Z, Gong P, Zhang H, Chen Y, | International journal of molec | 2022 | 0 |
| APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease. [PMID:35232622] | Parhizkar S, Holtzman DM | Seminars in immunology | 2022 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAG in their description or question text
Score: 0.613 · neurodegeneration · 2026-04-02
## Mechanistic Overview Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade starts from the
Score: 0.442 · neurodegeneration · 2026-04-22
## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts