Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lung Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | ACC, ADAM8, ALZHEIMER, ALZHEIMER'S DISEASE, ANXIETY, APOPTOSIS, ASCL1, ATG |
| Therapeutic Agents | Baicalein, Cus-Md@Cs, CuS-MD@CS, Fisetin, TKI |
| KG Connections | 662 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
graph TD
Lung_Cancer["Lung Cancer"]
Metastasis["Metastasis"]
Lung_Cancer -->|"therapeutic_target"| Metastasis
Apoptosis["Apoptosis"]
Lung_Cancer -->|"activates"| Apoptosis
Autophagy["Autophagy"]
Lung_Cancer -->|"activates"| Autophagy
Invasion["Invasion"]
Lung_Cancer -->|"activates"| Invasion
CANCER(["CANCER"])
CANCER -->|"associated_with"| Lung_Cancer
Cancer{"Cancer"}
Cancer -->|"associated_with"| Lung_Cancer
style Lung_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Metastasis | therapeutic_target | pathway | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Therapy-Induced Evolution | associated_with | process | 0.95 |
| Brain Metastasis | causes | disease | 0.95 |
| Single-Cell RNA Sequencing | biomarker_for | process | 0.90 |
| Apoptosis | inhibits | pathway | 0.90 |
| Microrna | therapeutic_target | pathway | 0.90 |
| Cell Cycle | activates | pathway | 0.90 |
| Immune Checkpoint | therapeutic_target | pathway | 0.90 |
| Ferroptosis | activates | pathway | 0.90 |
| Immunotherapy | therapeutic_target | pathway | 0.90 |
| PRPS1 | associated_with | protein | 0.85 |
| Gene Expression Changes | associated_with | process | 0.85 |
| Cancer Cell Evolution | involved_in | process | 0.85 |
| Vomiting | causes | phenotype | 0.80 |
| Abdominal Pain | causes | phenotype | 0.80 |
| Mitophagy | activates | pathway | 0.80 |
| Invasion | therapeutic_target | pathway | 0.80 |
| Tumor Microenvironment | activates | pathway | 0.80 |
| Differentiation | therapeutic_target | pathway | 0.80 |
| Egfr Signaling | therapeutic_target | pathway | 0.80 |
| Pi3K/Akt | therapeutic_target | pathway | 0.80 |
| Mapk | therapeutic_target | pathway | 0.80 |
| Immunotherapy | activates | pathway | 0.70 |
| Ampk Signaling | activates | pathway | 0.70 |
| Glycolysis | therapeutic_target | pathway | 0.70 |
| Immune Response | inhibits | pathway | 0.70 |
| Mtor | therapeutic_target | pathway | 0.70 |
| Erk Signaling | therapeutic_target | pathway | 0.70 |
| Apoptosis | regulates | pathway | 0.70 |
| Pi3K/Akt | activates | pathway | 0.70 |
| Nf-Κb | activates | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Mtor | inhibits | pathway | 0.70 |
| Epigenetic | regulates | pathway | 0.70 |
| Chemoresistance | activates | pathway | 0.70 |
| Mitophagy | regulates | pathway | 0.70 |
| Apoptosis | associated_with | pathway | 0.70 |
| Immune Response | activates | pathway | 0.70 |
| Wnt | therapeutic_target | pathway | 0.70 |
| Stem Cell | therapeutic_target | pathway | 0.70 |
| Tgf-Β | inhibits | pathway | 0.70 |
| Tumor Microenvironment | therapeutic_target | pathway | 0.70 |
| Mtor | activates | pathway | 0.70 |
| Checkpoint Inhibitor | therapeutic_target | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNA | therapeutic_target | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| EGFR | inhibits | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| EGFR | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Combustible Tobacco Products | risk_factor_for | drug | 1.00 |
| KRAS | therapeutic_target | gene | 0.95 |
| Cancer | causes | disease | 0.95 |
| CANCER | regulates | gene | 0.95 |
| APOPTOSIS | inhibits | gene | 0.95 |
| CANCER | causes | gene | 0.95 |
| Carcinoma | associated_with | disease | 0.95 |
| PI3K | therapeutic_target | gene | 0.95 |
| Carcinoma | therapeutic_target | disease | 0.95 |
| GENES | regulates | gene | 0.95 |
| GENES | activates | gene | 0.95 |
| CD8 | activates | gene | 0.95 |
| STAT3 | activates | gene | 0.95 |
| ERK | therapeutic_target | gene | 0.95 |
| FERROPTOSIS | activates | gene | 0.95 |
| Als | inhibits | disease | 0.95 |
| SATB2 | suppresses | gene | 0.95 |
| Baicalein | treats | compound | 0.90 |
| CuS-MD@CS | treats | drug | 0.90 |
| Head And Neck Cancer | associated_with | disease | 0.90 |
| Pneumonectomy | treats | process | 0.90 |
| Single-Cell RNA Sequencing | associated_with | process | 0.90 |
| TKI | treats | drug | 0.90 |
| Therapy | treats | process | 0.85 |
| ROS | activates | gene | 0.85 |
| Circulating Cell-free DNA | biomarker_for | biomarker | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Lung Cancer in their description or question text
No additional research found