concept

YAP/TAZ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YAP/TAZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

1Hypotheses

1Analyses

3Outgoing

45Incoming

0Experiments

1Debates

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💡 Concept Info

Name	YAP/TAZ
Key Genes/Proteins	PIEZO1, SPP1
Linked Hypotheses	1 hypotheses

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    YAP_TAZ["YAP/TAZ"]
    TAZ["TAZ"] -->|"inhibits"| YAP_TAZ
    YAP["YAP"] -->|"inhibits"| YAP_TAZ
    Breast_Cancer["Breast Cancer"] -->|"activates"| YAP_TAZ
    HIPPO["HIPPO"] -->|"regulates"| YAP_TAZ
    UBIQUITIN["UBIQUITIN"] -->|"regulates"| YAP_TAZ
    LATS1["LATS1"] -->|"regulates"| YAP_TAZ
    Cancer["Cancer"] -->|"regulates"| YAP_TAZ
    Als["Als"] -->|"regulates"| YAP_TAZ

Outgoing (3)

Target	Relation	Type	Str
cell homeostasis	maintains	process	0.85
SPP1	activates	gene	0.50
SPP1 transcription	regulates	process	0.50

Incoming (45)

Source	Relation	Type	Str
TAZ	activates	gene	0.70
YAP	activates	gene	0.70
Breast Cancer	activates	disease	0.70
YAP	inhibits	gene	0.70
TAZ	inhibits	gene	0.70
UBIQUITIN	regulates	gene	0.60
LATS1	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
GENES	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
Tumor	inhibits	disease	0.60
Cancer	inhibits	disease	0.60
CANCER	activates	gene	0.60
Tumor	activates	disease	0.60
Cancer	activates	disease	0.60
ATG	activates	gene	0.60
HIPPO	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AGING	activates	gene	0.60
DEMENTIA	activates	gene	0.60
Aging	activates	disease	0.60
Dementia	activates	disease	0.60
YAP	protects_against	gene	0.60
POSTN	activates	gene	0.60
Pulmonary Fibrosis	activates	disease	0.60
Fibrosis	activates	disease	0.60
PINK1	activates	gene	0.60
SPR	inhibits	gene	0.60
PARKIN	activates	gene	0.60
TAZ	protects_against	gene	0.60
Cancer	regulates	disease	0.60
Als	regulates	disease	0.60
MITOPHAGY	activates	gene	0.60
HIPPO	regulates	gene	0.60
HDAC1	activates	gene	0.60
TP53	activates	gene	0.60
CD8	activates	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
PIEZO1	protects_against	gene	0.60
LC3	activates	gene	0.60
PIEZO1	decreases_risk	gene	0.50
HIPPO	regulates	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

Related Research

Hypotheses and analyses mentioning YAP/TAZ in their description or question text

No additional research found