| Gene Symbol | ent-gene-a35fbac2 |
| Subcellular Localization | ### Parkinson's Disease |
| Aβ-mediated inhibition | Aβ oligomers suppress YAP/TAZ nuclear localization through multiple mechanisms |
| Hippo pathway dysregulation | Aβ activates MST1, increasing LATS1/2 activity and YAP/TAZ phosphorylation |
| Neuronal vulnerability | YAP/TAZ promote neuronal survival; their inhibition increases vulnerability |
| Neurogenesis impairment | Adult hippocampal neurogenesis requires YAP/TAZ; AD pathology suppresses this |
| Tau pathology interaction | Tau can affect YAP/TAZ subcellular localization |
| Dopaminergic neuron survival | YAP activation protects SNc neurons from degeneration |
| α-Synuclein effects | α-Synuclein can sequester TAZ, impairing its function |
| Autophagy regulation | TAZ promotes autophagy; loss contributes to protein aggregation |
| Mitochondrial function | YAP/TAZ influence mitochondrial dynamics and quality control |
| Therapeutic potential | YAP activators show promise in PD models |
| Motor neuron protection | YAP activation provides protection to motor neurons |
| TDP-43 pathology | YAP/TAZ can be sequestered by TDP-43 aggregates |
| Astrocyte reactivity | YAP/TAZ in astrocytes modulate neuroinflammation |
| Regenerative potential | Enhancing YAP/TAZ may promote neural repair |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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